| http://purl.uniprot.org/citations/12771218 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12771218 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12771218 | http://www.w3.org/2000/01/rdf-schema#comment | "The MCM8 protein from HeLa cells, a new member of the MCM family, co-isolates through several steps with MCM6 and MCM7, and MCM8 co-immunoprecipitates with MCM4, MCM6 and MCM7, proteins reportedly forming a helicase complex involved in initiation of DNA replication. MCM8 mRNA is expressed in placenta, lung and liver, but is also significantly expressed in adult heart, a tissue with a low percentage of proliferating cells. The MCM8 gene, consisting of 19 exons, is located contrapodal to a gene, consisting of 11 exons, encoding a homolog of the yeast GCD10 gene product. The region between these two transcription units, comprising as few as 62 bp, is TATA-less and highly GC-rich, containing multiple CpG units. MCM8 expression is altered in certain forms of neoplasia. In a case of choriocarcinoma MCM8 mRNA is aberrant, leading to expression of a protein lacking 16 amino acids. In several cases of colon adenocarcinoma MCM8 expression is greatly reduced relative to matched non-cancerous tissue. The potential helicase domain of MCM8 is different from those of other MCM proteins in that it is more homologous to canonical ATP-binding domains of other known helicases. Results suggest that MCM8 may interact with other MCM proteins to alter the function of the replicative MCM protein complex."xsd:string |
| http://purl.uniprot.org/citations/12771218 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkg395"xsd:string |
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| http://purl.uniprot.org/citations/12771218 | http://purl.uniprot.org/core/author | "Johnson E.M."xsd:string |
| http://purl.uniprot.org/citations/12771218 | http://purl.uniprot.org/core/author | "Johnson E.M."xsd:string |
| http://purl.uniprot.org/citations/12771218 | http://purl.uniprot.org/core/author | "Kinoshita Y."xsd:string |
| http://purl.uniprot.org/citations/12771218 | http://purl.uniprot.org/core/author | "Kinoshita Y."xsd:string |
| http://purl.uniprot.org/citations/12771218 | http://purl.uniprot.org/core/author | "Daniel D.C."xsd:string |
| http://purl.uniprot.org/citations/12771218 | http://purl.uniprot.org/core/author | "Daniel D.C."xsd:string |
| http://purl.uniprot.org/citations/12771218 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12771218 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12771218 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/12771218 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/12771218 | http://purl.uniprot.org/core/pages | "2915-2925"xsd:string |
| http://purl.uniprot.org/citations/12771218 | http://purl.uniprot.org/core/pages | "2915-2925"xsd:string |
| http://purl.uniprot.org/citations/12771218 | http://purl.uniprot.org/core/title | "A new member of the MCM protein family encoded by the human MCM8 gene, located contrapodal to GCD10 at chromosome band 20p12.3-13."xsd:string |
| http://purl.uniprot.org/citations/12771218 | http://purl.uniprot.org/core/title | "A new member of the MCM protein family encoded by the human MCM8 gene, located contrapodal to GCD10 at chromosome band 20p12.3-13."xsd:string |
| http://purl.uniprot.org/citations/12771218 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/12771218 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/12771218 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12771218 |
| http://purl.uniprot.org/citations/12771218 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12771218 |
| http://purl.uniprot.org/citations/12771218 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12771218 |
| http://purl.uniprot.org/citations/12771218 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12771218 |