| http://purl.uniprot.org/citations/12775683 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12775683 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12775683 | http://www.w3.org/2000/01/rdf-schema#comment | "Escherichia coli clinical strain Gre-1 collected in 2000 from a French hospital harboured a novel CTX-M-encoding gene, designated blaCTX-M-27. CTX-M-27 differed from CTX-M-14 only by the substitution D240G and was the third CTX-M enzyme harbouring this mutation after CTX-M-15 and CTX-M-16. The Gly-240-harbouring enzyme CTX-M-27 conferred to E. coli higher MICs of ceftazidime (MIC, 8 versus 1 mg/L) than did the Asp-240-harbouring CTX-M-14 enzyme. Comparison of CTX-M-14 and CTX-M-27 showed that residue Gly-240 decreased Km for ceftazidime (205 versus 940 microM), but decreased hydrolytic activity against good substrates, such as cefotaxime (kcat, 113 versus 415 s-1), probably owing to the alteration of beta3 strand positioning during the catalytic process."xsd:string |
| http://purl.uniprot.org/citations/12775683 | http://purl.org/dc/terms/identifier | "doi:10.1093/jac/dkg256"xsd:string |
| http://purl.uniprot.org/citations/12775683 | http://purl.org/dc/terms/identifier | "doi:10.1093/jac/dkg256"xsd:string |
| http://purl.uniprot.org/citations/12775683 | http://purl.uniprot.org/core/author | "Chanal C."xsd:string |
| http://purl.uniprot.org/citations/12775683 | http://purl.uniprot.org/core/author | "Chanal C."xsd:string |
| http://purl.uniprot.org/citations/12775683 | http://purl.uniprot.org/core/author | "Sirot D."xsd:string |
| http://purl.uniprot.org/citations/12775683 | http://purl.uniprot.org/core/author | "Sirot D."xsd:string |
| http://purl.uniprot.org/citations/12775683 | http://purl.uniprot.org/core/author | "Sirot J."xsd:string |
| http://purl.uniprot.org/citations/12775683 | http://purl.uniprot.org/core/author | "Sirot J."xsd:string |
| http://purl.uniprot.org/citations/12775683 | http://purl.uniprot.org/core/author | "Bonnet R."xsd:string |
| http://purl.uniprot.org/citations/12775683 | http://purl.uniprot.org/core/author | "Bonnet R."xsd:string |
| http://purl.uniprot.org/citations/12775683 | http://purl.uniprot.org/core/author | "De Champs C."xsd:string |
| http://purl.uniprot.org/citations/12775683 | http://purl.uniprot.org/core/author | "De Champs C."xsd:string |
| http://purl.uniprot.org/citations/12775683 | http://purl.uniprot.org/core/author | "Baraduc R."xsd:string |
| http://purl.uniprot.org/citations/12775683 | http://purl.uniprot.org/core/author | "Baraduc R."xsd:string |
| http://purl.uniprot.org/citations/12775683 | http://purl.uniprot.org/core/author | "Recule C."xsd:string |
| http://purl.uniprot.org/citations/12775683 | http://purl.uniprot.org/core/author | "Recule C."xsd:string |
| http://purl.uniprot.org/citations/12775683 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12775683 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12775683 | http://purl.uniprot.org/core/name | "J. Antimicrob. Chemother."xsd:string |
| http://purl.uniprot.org/citations/12775683 | http://purl.uniprot.org/core/name | "J Antimicrob Chemother"xsd:string |
| http://purl.uniprot.org/citations/12775683 | http://purl.uniprot.org/core/pages | "29-35"xsd:string |
| http://purl.uniprot.org/citations/12775683 | http://purl.uniprot.org/core/pages | "29-35"xsd:string |