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| http://purl.uniprot.org/citations/12776204 | http://www.w3.org/2000/01/rdf-schema#comment | "Triggering receptors expressed by myeloid cells (TREMs) belong to a rapidly expanding family of receptors that include activating and inhibitory isoforms encoded by a gene cluster linked to the MHC. TREM1 and TREM2 activate myeloid cells by signalling through the adaptor protein DAP12. TREM1 triggers phagocyte secretion of pro-inflammatory chemokines and cytokines, amplifying the inflammation that is induced by bacteria and fungi. TREM2 activates monocyte-derived dendritic cells and regulates osteoclast development. Remarkably, TREM2 deficiency leads to a severe disease that is characterized by bone cysts and demyelination of the central nervous system, which results in dementia, implying that the function of TREM2 extends beyond the immune system."xsd:string |
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| http://purl.uniprot.org/citations/12776204 | http://purl.uniprot.org/core/author | "Colonna M."xsd:string |
| http://purl.uniprot.org/citations/12776204 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12776204 | http://purl.uniprot.org/core/name | "Nat Rev Immunol"xsd:string |
| http://purl.uniprot.org/citations/12776204 | http://purl.uniprot.org/core/pages | "445-453"xsd:string |
| http://purl.uniprot.org/citations/12776204 | http://purl.uniprot.org/core/title | "TREMs in the immune system and beyond."xsd:string |
| http://purl.uniprot.org/citations/12776204 | http://purl.uniprot.org/core/volume | "3"xsd:string |
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