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http://purl.uniprot.org/citations/12780527http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12780527http://www.w3.org/2000/01/rdf-schema#comment"

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Helicobacter pylori infection is associated with chronic gastritis, peptic ulcer disease, gastric adenocarcinoma and MALT lymphoma. We previously found high-grade lymphoma after 13 months' H. pylori infection in C57BL/6 mice. In this study we followed H. pylori infection by three different isolates in C57BL/6 and Balb/cA mice for 23 months. Six-week-old C57BL/6 and Balb/cA mice were infected with H. pylori strains 119p (CagA+, VacA+), SS1 (CagA+, VacA+) and G50 (CagA-, VacA-). Mice were followed at 2 weeks, 10 weeks and 23 months post-inoculation (p.i.) by culture, histopathology and serology. Strain G50 was only reisolated from mice 2 weeks p.i. There was no difference in colonization between strain 119p and SS1 at 10 weeks p.i., whereas SS1 gave 100% colonization versus 119p gave 50% 23 months p.i. Interestingly, the inflammation score was higher in mice infected with strain 119p than with SS1 10-week p.i., and there were lymphoepithelial lesions in mice infected with strain 119p and G50 but not with SS1 at 23 months post-infection. Eight mice infected with strains 119p and G50 developed gastric lymphoma (grade 5 and 4). One C57BL/6 mouse infected with strain 119p developed hepatocellular carcinoma after 23 months. Immunoblot showed specific bands of 26-33 kDa against H. pylori in infected mice, and two mice infected with strain SSI reacted with antibodies to the 120 kDa CagA toxin.

Conclusion

A reproducible animal model for H. pylori-induced lymphoma and possibly hepatocellular carcinoma is described. Strain diversity may lead to different outcomes of H. pylori infection."xsd:string
http://purl.uniprot.org/citations/12780527http://purl.org/dc/terms/identifier"doi:10.1034/j.1600-0463.2003.1110410.x"xsd:string
http://purl.uniprot.org/citations/12780527http://purl.uniprot.org/core/author"Wang X."xsd:string
http://purl.uniprot.org/citations/12780527http://purl.uniprot.org/core/author"Wadstrom T."xsd:string
http://purl.uniprot.org/citations/12780527http://purl.uniprot.org/core/author"Svensson M."xsd:string
http://purl.uniprot.org/citations/12780527http://purl.uniprot.org/core/author"Ljungh A."xsd:string
http://purl.uniprot.org/citations/12780527http://purl.uniprot.org/core/author"Willen R."xsd:string
http://purl.uniprot.org/citations/12780527http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12780527http://purl.uniprot.org/core/name"APMIS"xsd:string
http://purl.uniprot.org/citations/12780527http://purl.uniprot.org/core/pages"514-522"xsd:string
http://purl.uniprot.org/citations/12780527http://purl.uniprot.org/core/title"Two-year follow-up of Helicobacter pylori infection in C57BL/6 and Balb/cA mice."xsd:string
http://purl.uniprot.org/citations/12780527http://purl.uniprot.org/core/volume"111"xsd:string
http://purl.uniprot.org/citations/12780527http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12780527
http://purl.uniprot.org/citations/12780527http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12780527
http://purl.uniprot.org/uniprot/#_P70441-mappedCitation-12780527http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12780527
http://purl.uniprot.org/uniprot/#_Q3TG37-mappedCitation-12780527http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12780527
http://purl.uniprot.org/uniprot/P70441http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/12780527
http://purl.uniprot.org/uniprot/Q3TG37http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/12780527