| http://purl.uniprot.org/citations/12783879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12783879 | http://www.w3.org/2000/01/rdf-schema#comment | "Suppressors of cytokine signaling (SOCS) have been implicated in regulation of T-cell activation and cytokine-mediated differentiation of T-helper cells. In this study we have characterized the pattern of SOCS expression in naïve and activated primary T-helper cells, examined whether expression of SOCS genes is regulated by cytokine or T-cell receptor signaling, and analyzed the function of SOCS in differentiated T-cells. We show that SOCS1, SOCS2, SOCS3, CIS (cytokine-induced SH2 protein) genes are constitutively expressed in naïve T-helper cells, with SOCS3 being the most abundant. Antigen stimulation of naïve T-helper cells down-regulates SOCS3 expression and concomitantly up-regulates SOCS1, SOCS2, and CIS gene transcription, suggesting that SOCS genes are regulated differentially by T-cell activation. Down-regulation of SOCS3 expression is subsequently followed by gradual increase in SOCS3 level and corresponding decline in interleukin 2 (IL-2) secretion. In fact, SOCS3 mRNA levels are inversely correlated with the amount of IL-2 secretion and proliferative responses of differentiating T-helper cells, suggesting mutually antagonistic effects of SOCS3 and IL-2 and feedback regulation of T-cell activation by SOCS3. Furthermore, the degree of SOCS3 inhibition is antigen concentration-dependent and is mediated in part by growth factor independence-1, a T-cell transcription factor that regulates S-phase entry in T-cells. Forced overexpression of SOCS3 inhibits proliferation of T-helper cells, whereas depletion of endogenous SOCS3 by antisense SOCS3 cDNA enhances T-cell receptor- and cytokine-induced proliferation. Taken together, these results suggest a role for SOCS3 in maintaining T-helper cells in a quiescent state. Transient inhibition of SOCS3 by antigen stimulation may therefore be essential in allowing activation of resting T-cells."xsd:string |
| http://purl.uniprot.org/citations/12783879 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m300489200"xsd:string |
| http://purl.uniprot.org/citations/12783879 | http://purl.uniprot.org/core/author | "Gery I."xsd:string |
| http://purl.uniprot.org/citations/12783879 | http://purl.uniprot.org/core/author | "Yu C.R."xsd:string |
| http://purl.uniprot.org/citations/12783879 | http://purl.uniprot.org/core/author | "Egwuagu C.E."xsd:string |
| http://purl.uniprot.org/citations/12783879 | http://purl.uniprot.org/core/author | "Vistica B.P."xsd:string |
| http://purl.uniprot.org/citations/12783879 | http://purl.uniprot.org/core/author | "Mahdi R.M."xsd:string |
| http://purl.uniprot.org/citations/12783879 | http://purl.uniprot.org/core/author | "Ebong S."xsd:string |
| http://purl.uniprot.org/citations/12783879 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12783879 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12783879 | http://purl.uniprot.org/core/pages | "29752-29759"xsd:string |
| http://purl.uniprot.org/citations/12783879 | http://purl.uniprot.org/core/title | "Suppressor of cytokine signaling 3 regulates proliferation and activation of T-helper cells."xsd:string |
| http://purl.uniprot.org/citations/12783879 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12783879 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12783879 |
| http://purl.uniprot.org/citations/12783879 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12783879 |
| http://purl.uniprot.org/uniprot/#_O35718-mappedCitation-12783879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12783879 |
| http://purl.uniprot.org/uniprot/#_Q3U9J8-mappedCitation-12783879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12783879 |
| http://purl.uniprot.org/uniprot/Q3U9J8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12783879 |
| http://purl.uniprot.org/uniprot/O35718 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12783879 |