| http://purl.uniprot.org/citations/12786971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12786971 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of the present work was to verify whether an impairment of subtype 5 metabotropic glutamate receptor-mediated neurotransmission did occur in the aged striatum. To this end, the ability of the subtype 5 metabotropic glutamate receptor agonist, RS-2-chloro-5-hydroxyphenylglycine, to stimulate phosphoinositide hydrolysis and to potentiate N-methyl-d-aspartate-induced effects in striatal slices from young (3 months) and aged (24 months) rats was compared. The ability of RS-2-chloro-5-hydroxyphenylglycine to induce maximal phosphoinositide turnover and to potentiate N-methyl-d-aspartate effects was significantly reduced in slices from old vs. young rats. These changes were associated with a significant reduction in the expression of subtype 5 metabotropic glutamate receptor protein (-28.8%) and phospholipase C-beta1 (-55.8%) in old striata, while receptor messenger ribonucleic acid expression was unchanged. These results show that the signalling associated with subtype 5 metabotropic glutamate receptors undergoes significant age-related changes and that a reduced expression of subtype 5 metabotropic glutamate receptors and, more importantly, phospholipase C-beta1 may account for the functional decline of subtype 5 metabotropic glutamate receptors."xsd:string |
| http://purl.uniprot.org/citations/12786971 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1460-9568.2003.02649.x"xsd:string |
| http://purl.uniprot.org/citations/12786971 | http://purl.uniprot.org/core/author | "Gro M.C."xsd:string |
| http://purl.uniprot.org/citations/12786971 | http://purl.uniprot.org/core/author | "Gaudi S."xsd:string |
| http://purl.uniprot.org/citations/12786971 | http://purl.uniprot.org/core/author | "Passarelli F."xsd:string |
| http://purl.uniprot.org/citations/12786971 | http://purl.uniprot.org/core/author | "Potenza R.L."xsd:string |
| http://purl.uniprot.org/citations/12786971 | http://purl.uniprot.org/core/author | "Popoli P."xsd:string |
| http://purl.uniprot.org/citations/12786971 | http://purl.uniprot.org/core/author | "Galluzzo M."xsd:string |
| http://purl.uniprot.org/citations/12786971 | http://purl.uniprot.org/core/author | "Domenici M.R."xsd:string |
| http://purl.uniprot.org/citations/12786971 | http://purl.uniprot.org/core/author | "Massotti M."xsd:string |
| http://purl.uniprot.org/citations/12786971 | http://purl.uniprot.org/core/author | "Pintor A."xsd:string |
| http://purl.uniprot.org/citations/12786971 | http://purl.uniprot.org/core/author | "Reggio R."xsd:string |
| http://purl.uniprot.org/citations/12786971 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12786971 | http://purl.uniprot.org/core/name | "Eur J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/12786971 | http://purl.uniprot.org/core/pages | "2047-2055"xsd:string |
| http://purl.uniprot.org/citations/12786971 | http://purl.uniprot.org/core/title | "Metabotropic glutamate receptor 5 (mGluR5)-mediated phosphoinositide hydrolysis and NMDA-potentiating effects are blunted in the striatum of aged rats: a possible additional mechanism in striatal senescence."xsd:string |
| http://purl.uniprot.org/citations/12786971 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/12786971 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12786971 |
| http://purl.uniprot.org/citations/12786971 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12786971 |
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