| http://purl.uniprot.org/citations/12788886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12788886 | http://www.w3.org/2000/01/rdf-schema#comment | "Our previous results have suggested that genes outside the human leukocyte antigen (HLA) class II locus may affect the phenotype of type 2 diabetic patients from families with both type 1 and type 2 diabetes (mixed type 1/2). To study whether the TNF alpha gene could be such a modifying gene, we studied TNF alpha promoter polymorphisms (G-->A substitution at positions -308 and -238) in relation to HLA-DQB1 genotypes in type 2 patients from mixed type 1/2 families or common type 2 diabetes families as well as in patients with adult-onset type 1 diabetes and control subjects. The TNF alpha(308) AA/AG genotype frequency was increased in adult onset type 1 patients (55%, 69 of 126), but it was similar in type 2 patients from type 1/2 families (35%, 33/93) or common type 2 families (31%, 122 of 395), compared with controls (33%, 95/284; P < 0.0001 vs. type 1). The TNF alpha(308) A and DQB1*02 alleles were in linkage disequilibrium in type 1 patients (Ds = 0.81; P < 0.001 vs. Ds = 0.25 in controls) and type 2 patients from type 1/2 families (Ds = 0.59, P < 0.05 vs. controls) but not in common type 2 patients (Ds = 0.39). The polymorphism was associated with an insulin-deficient phenotype in the type 2 patients from type 1/2 families only together with DQB*02, whereas the common type 2 patients with AA/AG had lower waist to hip ratio [0.92 (0.12) vs. 0.94 (0.11), P = 0.008] and lower fasting C-peptide concentration [0.48 (0.47) vs. 0.62 (0.46) nmol/liter, P = 0.020] than those with GG, independently of the presence of DQB1*02. In conclusion, TNF alpha is unlikely to be the second gene in the HLA area responsible for our previous findings in type 1/2 patients. However, we could show an association between TNF alpha(308) polymorphism and the phenotype of common type 2 diabetes."xsd:string |
| http://purl.uniprot.org/citations/12788886 | http://purl.org/dc/terms/identifier | "doi:10.1210/jc.2002-020506"xsd:string |
| http://purl.uniprot.org/citations/12788886 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/12788886 | http://purl.uniprot.org/core/author | "Weng J."xsd:string |
| http://purl.uniprot.org/citations/12788886 | http://purl.uniprot.org/core/author | "Groop L."xsd:string |
| http://purl.uniprot.org/citations/12788886 | http://purl.uniprot.org/core/author | "Nilsson A."xsd:string |
| http://purl.uniprot.org/citations/12788886 | http://purl.uniprot.org/core/author | "Tuomi T."xsd:string |
| http://purl.uniprot.org/citations/12788886 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12788886 | http://purl.uniprot.org/core/name | "J Clin Endocrinol Metab"xsd:string |
| http://purl.uniprot.org/citations/12788886 | http://purl.uniprot.org/core/pages | "2767-2774"xsd:string |
| http://purl.uniprot.org/citations/12788886 | http://purl.uniprot.org/core/title | "A combination of human leukocyte antigen DQB1*02 and the tumor necrosis factor alpha promoter G308A polymorphism predisposes to an insulin-deficient phenotype in patients with type 2 diabetes."xsd:string |
| http://purl.uniprot.org/citations/12788886 | http://purl.uniprot.org/core/volume | "88"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A076L4M5-mappedCitation-12788886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12788886 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C7I5-mappedCitation-12788886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12788886 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C853-mappedCitation-12788886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12788886 |
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