| http://purl.uniprot.org/citations/12788944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12788944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12788944 | http://www.w3.org/2000/01/rdf-schema#comment | "The exosome is a complex of 3' --> 5' exoribonucleases that functions in a variety of cellular processes, all concerning the processing or degradation of RNA. Paradoxically, the previously described cDNA for the human autoantigenic exosome subunit PM/Scl-75 (Alderuccio, F., Chan, E. K., and Tan, E. M. (1991) J. Exp. Med. 173, 941-952) encodes a polypeptide that failed to interact with the exosome complex. Here, we describe the cloning of a more complete cDNA for PM/Scl-75 encoding 84 additional amino acids at its N terminus. We show that only the longer polypeptide is able to associate with the exosome complex. This interaction is most likely mediated by protein-protein interactions with two other exosome subunits, hRrp46p and hRrp41p, one of which was confirmed in a mammalian two-hybrid system. In addition we show that the putative nuclear localization signal present in the C-terminal region of PM/Scl-75 is sufficient, although not essential for nuclear localization of the protein. Moreover, the deletion of this element abrogated the nucleolar accumulation of PM/Scl-75, although its association with the exosome was not disturbed. This suggests that this basic element of PM/Scl-75 plays a role in targeting the exosome to the nucleolus."xsd:string |
| http://purl.uniprot.org/citations/12788944 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m302488200"xsd:string |
| http://purl.uniprot.org/citations/12788944 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m302488200"xsd:string |
| http://purl.uniprot.org/citations/12788944 | http://purl.uniprot.org/core/author | "Raijmakers R."xsd:string |
| http://purl.uniprot.org/citations/12788944 | http://purl.uniprot.org/core/author | "Raijmakers R."xsd:string |
| http://purl.uniprot.org/citations/12788944 | http://purl.uniprot.org/core/author | "van Venrooij W.J."xsd:string |
| http://purl.uniprot.org/citations/12788944 | http://purl.uniprot.org/core/author | "van Venrooij W.J."xsd:string |
| http://purl.uniprot.org/citations/12788944 | http://purl.uniprot.org/core/author | "Egberts W.V."xsd:string |
| http://purl.uniprot.org/citations/12788944 | http://purl.uniprot.org/core/author | "Egberts W.V."xsd:string |
| http://purl.uniprot.org/citations/12788944 | http://purl.uniprot.org/core/author | "Pruijn G.J."xsd:string |
| http://purl.uniprot.org/citations/12788944 | http://purl.uniprot.org/core/author | "Pruijn G.J."xsd:string |
| http://purl.uniprot.org/citations/12788944 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12788944 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12788944 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12788944 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12788944 | http://purl.uniprot.org/core/pages | "30698-30704"xsd:string |
| http://purl.uniprot.org/citations/12788944 | http://purl.uniprot.org/core/pages | "30698-30704"xsd:string |
| http://purl.uniprot.org/citations/12788944 | http://purl.uniprot.org/core/title | "The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus."xsd:string |
| http://purl.uniprot.org/citations/12788944 | http://purl.uniprot.org/core/title | "The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus."xsd:string |
| http://purl.uniprot.org/citations/12788944 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12788944 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12788944 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12788944 |
| http://purl.uniprot.org/citations/12788944 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12788944 |