| http://purl.uniprot.org/citations/12792699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12792699 | http://www.w3.org/2000/01/rdf-schema#comment | "High levels of von Willebrand factor (vWF) have been associated with cardiovascular disease. The A allele of the -1185A/G polymorphism in the 5'-regulatory region of the vWF gene was associated with the highest plasma vWF levels in a normal population. To examine the association between -1185A/G polymorphism and coronary artery disease (CAD), 173 Brazilian Caucasian subjects submitted to coronary angiography were studied. Of these, 57 (33%) had normal coronary arteries (control group) and 116 (67%) had CAD (patient group). Plasma vWF levels were higher in patients (145 U/dl) than in controls (130 U/dl), but the differences were significant only for O blood group subjects. Polymerase chain reaction amplification of the 864-bp vWF promoter region followed by AccII restriction digestion was used to identify the -1185A/G genotypes. The -1185A allele frequency was 43.1% in patients and 44.7% in controls. Allele and genotype frequencies were not significantly different between patients and controls. No association was observed between the -1185A/G genotypes and plasma vWF levels in patients or controls. These results suggest that -1185A/G polymorphism is not an independent risk factor for CAD."xsd:string |
| http://purl.uniprot.org/citations/12792699 | http://purl.org/dc/terms/identifier | "doi:10.1590/s0100-879x2003000600005"xsd:string |
| http://purl.uniprot.org/citations/12792699 | http://purl.uniprot.org/core/author | "Simon D."xsd:string |
| http://purl.uniprot.org/citations/12792699 | http://purl.uniprot.org/core/author | "Roisenberg I."xsd:string |
| http://purl.uniprot.org/citations/12792699 | http://purl.uniprot.org/core/author | "Ghisleni G.C."xsd:string |
| http://purl.uniprot.org/citations/12792699 | http://purl.uniprot.org/core/author | "Manfroi W.C."xsd:string |
| http://purl.uniprot.org/citations/12792699 | http://purl.uniprot.org/core/author | "Paludo C.A."xsd:string |
| http://purl.uniprot.org/citations/12792699 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12792699 | http://purl.uniprot.org/core/name | "Braz J Med Biol Res"xsd:string |
| http://purl.uniprot.org/citations/12792699 | http://purl.uniprot.org/core/pages | "709-714"xsd:string |
| http://purl.uniprot.org/citations/12792699 | http://purl.uniprot.org/core/title | "Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease."xsd:string |
| http://purl.uniprot.org/citations/12792699 | http://purl.uniprot.org/core/volume | "36"xsd:string |
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