| http://purl.uniprot.org/citations/12794170 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12794170 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12794170 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies increasingly point to a pivotal role of CD4(+) T cells in human anti-tumor immune response. Here we show that lymphocytes purified from a tumor-infiltrated lymph node of a melanoma patient that had remained disease free for 10 years after surgical resection of a lymph node metastasis comprised oligoclonal class II HLA-restricted CD4(+) T cells recognizing the autologous tumor cells in vitro. In fact, the CD4(+) T cell clones isolated from these lymphocytes displayed a tumor-specific, cytotoxic activity in addition to a Th1-like cytokine profile. By a genetic approach, a peptide derived from a mutated receptor-like protein tyrosine phosphatase kappa was identified as a novel HLA-DR10-restricted epitope for all the melanoma-specific CD4(+) T cell clones. The immunogenic peptide was shown to contain the mutated residue that was crucial for T cell recognition and activation. Moreover, a systemic immunity against the mutated peptide was detectable in the patient's peripheral blood T lymphocytes obtained during the disease-free period of follow-up. These findings further support the relevance of CD4(+) T cells directed against mutated epitopes in tumor immunity and provide the rationale for a possible usage of mutated, tumor-specific Ags for immunotherapy of human cancer."xsd:string |
| http://purl.uniprot.org/citations/12794170 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.170.12.6363"xsd:string |
| http://purl.uniprot.org/citations/12794170 | http://purl.uniprot.org/core/author | "Greco A."xsd:string |
| http://purl.uniprot.org/citations/12794170 | http://purl.uniprot.org/core/author | "Greco A."xsd:string |
| http://purl.uniprot.org/citations/12794170 | http://purl.uniprot.org/core/author | "Robbins P.F."xsd:string |
| http://purl.uniprot.org/citations/12794170 | http://purl.uniprot.org/core/author | "Robbins P.F."xsd:string |
| http://purl.uniprot.org/citations/12794170 | http://purl.uniprot.org/core/author | "Castelli C."xsd:string |
| http://purl.uniprot.org/citations/12794170 | http://purl.uniprot.org/core/author | "Castelli C."xsd:string |
| http://purl.uniprot.org/citations/12794170 | http://purl.uniprot.org/core/author | "Parmiani G."xsd:string |
| http://purl.uniprot.org/citations/12794170 | http://purl.uniprot.org/core/author | "Parmiani G."xsd:string |
| http://purl.uniprot.org/citations/12794170 | http://purl.uniprot.org/core/author | "Rini F."xsd:string |
| http://purl.uniprot.org/citations/12794170 | http://purl.uniprot.org/core/author | "Rini F."xsd:string |
| http://purl.uniprot.org/citations/12794170 | http://purl.uniprot.org/core/author | "Rivoltini L."xsd:string |
| http://purl.uniprot.org/citations/12794170 | http://purl.uniprot.org/core/author | "Rivoltini L."xsd:string |
| http://purl.uniprot.org/citations/12794170 | http://purl.uniprot.org/core/author | "Deho P."xsd:string |
| http://purl.uniprot.org/citations/12794170 | http://purl.uniprot.org/core/author | "Deho P."xsd:string |
| http://purl.uniprot.org/citations/12794170 | http://purl.uniprot.org/core/author | "Mazzocchi A."xsd:string |
| http://purl.uniprot.org/citations/12794170 | http://purl.uniprot.org/core/author | "Mazzocchi A."xsd:string |
| http://purl.uniprot.org/citations/12794170 | http://purl.uniprot.org/core/author | "Novellino L."xsd:string |
| http://purl.uniprot.org/citations/12794170 | http://purl.uniprot.org/core/author | "Novellino L."xsd:string |
| http://purl.uniprot.org/citations/12794170 | http://purl.uniprot.org/core/author | "Renkvist N."xsd:string |
| http://purl.uniprot.org/citations/12794170 | http://purl.uniprot.org/core/author | "Renkvist N."xsd:string |
| http://purl.uniprot.org/citations/12794170 | http://purl.uniprot.org/core/author | "Squarcina P."xsd:string |