| http://purl.uniprot.org/citations/12796776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12796776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12796776 | http://www.w3.org/2000/01/rdf-schema#comment | "During activation, T cells express receptors for receiving positive and negative costimulatory signals. Here we identify the B and T lymphocyte attenuator (BTLA), an immunoglobulin domain-containing glycoprotein with two immunoreceptor tyrosine-based inhibitory motifs. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. Crosslinking BTLA with antigen receptors induces its tyrosine phosphorylation and association with the Src homology domain 2 (SH2)-containing protein tyrosine phosphatases SHP-1 and SHP-2, and attenuates production of interleukin 2 (IL-2). BTLA-deficient T cells show increased proliferation, and BTLA-deficient mice have increased specific antibody responses and enhanced sensitivity to experimental autoimmune encephalomyelitis. B7x, a peripheral homolog of B7, is a ligand of BTLA. Thus, BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1)."xsd:string |
| http://purl.uniprot.org/citations/12796776 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni944"xsd:string |
| http://purl.uniprot.org/citations/12796776 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni944"xsd:string |
| http://purl.uniprot.org/citations/12796776 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/12796776 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/12796776 | http://purl.uniprot.org/core/author | "Watanabe N."xsd:string |
| http://purl.uniprot.org/citations/12796776 | http://purl.uniprot.org/core/author | "Watanabe N."xsd:string |
| http://purl.uniprot.org/citations/12796776 | http://purl.uniprot.org/core/author | "Murphy K.M."xsd:string |
| http://purl.uniprot.org/citations/12796776 | http://purl.uniprot.org/core/author | "Murphy K.M."xsd:string |
| http://purl.uniprot.org/citations/12796776 | http://purl.uniprot.org/core/author | "Zang X."xsd:string |
| http://purl.uniprot.org/citations/12796776 | http://purl.uniprot.org/core/author | "Zang X."xsd:string |
| http://purl.uniprot.org/citations/12796776 | http://purl.uniprot.org/core/author | "Zimmerman N."xsd:string |
| http://purl.uniprot.org/citations/12796776 | http://purl.uniprot.org/core/author | "Zimmerman N."xsd:string |
| http://purl.uniprot.org/citations/12796776 | http://purl.uniprot.org/core/author | "Murphy T.L."xsd:string |
| http://purl.uniprot.org/citations/12796776 | http://purl.uniprot.org/core/author | "Murphy T.L."xsd:string |
| http://purl.uniprot.org/citations/12796776 | http://purl.uniprot.org/core/author | "Russell J.H."xsd:string |
| http://purl.uniprot.org/citations/12796776 | http://purl.uniprot.org/core/author | "Russell J.H."xsd:string |
| http://purl.uniprot.org/citations/12796776 | http://purl.uniprot.org/core/author | "Sim J."xsd:string |
| http://purl.uniprot.org/citations/12796776 | http://purl.uniprot.org/core/author | "Sim J."xsd:string |
| http://purl.uniprot.org/citations/12796776 | http://purl.uniprot.org/core/author | "Allison J.P."xsd:string |
| http://purl.uniprot.org/citations/12796776 | http://purl.uniprot.org/core/author | "Allison J.P."xsd:string |
| http://purl.uniprot.org/citations/12796776 | http://purl.uniprot.org/core/author | "Fallarino F."xsd:string |
| http://purl.uniprot.org/citations/12796776 | http://purl.uniprot.org/core/author | "Fallarino F."xsd:string |