| http://purl.uniprot.org/citations/12798298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12798298 | http://www.w3.org/2000/01/rdf-schema#comment | "Hindbrain development is a well-characterised segmentation process in vertebrates. The bZip transcription factor MafB/kreisler is specifically expressed in rhombomeres (r) 5 and 6 of the developing vertebrate hindbrain and is required for proper caudal hindbrain segmentation. Here, we provide evidence that the mouse protooncogene c-jun, which encodes a member of the bZip family, is coexpressed with MafB in prospective r5 and r6. Analysis of mouse mutants suggests that c-jun expression in these territories is dependent on MafB but independent of the zinc-finger transcription factor Krox20, another essential determinant of r5 development. Loss- and gain-of-function studies, performed in mouse and chick embryos, respectively, demonstrate that c-Jun participates, together with MafB and Krox20, in the transcriptional activation of the Hoxb3 gene in r5. The action of c-Jun is likely to be direct, since c-Jun homodimers and c-Jun/MafB heterodimers can bind to essential regulatory elements within the transcriptional enhancer responsible for Hoxb3 expression in r5. These data indicate that c-Jun acts both as a downstream effector and a cofactor of MafB and belongs to the complex network of factors governing hindbrain patterning."xsd:string |
| http://purl.uniprot.org/citations/12798298 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0012-1606(03)00135-0"xsd:string |
| http://purl.uniprot.org/citations/12798298 | http://purl.uniprot.org/core/author | "Charnay P."xsd:string |
| http://purl.uniprot.org/citations/12798298 | http://purl.uniprot.org/core/author | "Yaniv M."xsd:string |
| http://purl.uniprot.org/citations/12798298 | http://purl.uniprot.org/core/author | "Pujades C."xsd:string |
| http://purl.uniprot.org/citations/12798298 | http://purl.uniprot.org/core/author | "Giudicelli F."xsd:string |
| http://purl.uniprot.org/citations/12798298 | http://purl.uniprot.org/core/author | "Mechta-Grigoriou F."xsd:string |
| http://purl.uniprot.org/citations/12798298 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12798298 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/12798298 | http://purl.uniprot.org/core/pages | "419-431"xsd:string |
| http://purl.uniprot.org/citations/12798298 | http://purl.uniprot.org/core/title | "c-jun regulation and function in the developing hindbrain."xsd:string |
| http://purl.uniprot.org/citations/12798298 | http://purl.uniprot.org/core/volume | "258"xsd:string |
| http://purl.uniprot.org/citations/12798298 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12798298 |
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