| http://purl.uniprot.org/citations/12804595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12804595 | http://www.w3.org/2000/01/rdf-schema#comment | "The objective of this study was to characterize the apoptotic pathways activated by fast neutrons in the human lymphoblastoid cell line TK6 and in its p53 -/-derivative. Our results demonstrate that while p53 is not required for neutron-induced apoptosis, as previously shown, it does affect the kinetics of apoptosis and the molecular pathways leading to the activation of effector caspases. Indeed, rapid p53-dependent apoptosis was associated with the activation of caspase 9, 8, 3, and 7 and the cleavage of BID by caspase 8. In contrast, the slow-occurring p53-independent apoptotic process, mediated by caspase 7, took place without BID cleavage and loss of transmembrane mitochondrial potential. Altogether, our findings highlight an essential role for caspase 8-mediated BID cleavage, in the course of p53-dependent apoptosis triggered by fast neutrons in lymphoid cells. They also demonstrate that this mechanism is not involved in p53-independent apoptosis."xsd:string |
| http://purl.uniprot.org/citations/12804595 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(03)01004-0"xsd:string |
| http://purl.uniprot.org/citations/12804595 | http://purl.uniprot.org/core/author | "Coelho D."xsd:string |
| http://purl.uniprot.org/citations/12804595 | http://purl.uniprot.org/core/author | "Fischer B."xsd:string |
| http://purl.uniprot.org/citations/12804595 | http://purl.uniprot.org/core/author | "Bergerat J.P."xsd:string |
| http://purl.uniprot.org/citations/12804595 | http://purl.uniprot.org/core/author | "Dufour P."xsd:string |
| http://purl.uniprot.org/citations/12804595 | http://purl.uniprot.org/core/author | "Bischoff P."xsd:string |
| http://purl.uniprot.org/citations/12804595 | http://purl.uniprot.org/core/author | "Denis J.M."xsd:string |
| http://purl.uniprot.org/citations/12804595 | http://purl.uniprot.org/core/author | "Gueulette J."xsd:string |
| http://purl.uniprot.org/citations/12804595 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12804595 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/12804595 | http://purl.uniprot.org/core/pages | "516-522"xsd:string |
| http://purl.uniprot.org/citations/12804595 | http://purl.uniprot.org/core/title | "Caspase 8-mediated cleavage of the pro-apoptotic BCL-2 family member BID in p53-dependent apoptosis."xsd:string |
| http://purl.uniprot.org/citations/12804595 | http://purl.uniprot.org/core/volume | "306"xsd:string |
| http://purl.uniprot.org/citations/12804595 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12804595 |
| http://purl.uniprot.org/citations/12804595 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12804595 |
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| http://purl.uniprot.org/uniprot/#_A0A087X1Q1-mappedCitation-12804595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12804595 |
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