| http://purl.uniprot.org/citations/12804791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12804791 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-1 (IL-1) mediates psychological stress responses by regulating monoamine metabolism and secretion of corticotropin-releasing factor, and is therefore, implicated in various psychiatric diseases. To evaluate the contribution of IL-1 signaling to the brain pathology of schizophrenia, we measured protein and/or mRNA levels for IL-1beta and endogenous IL-1 receptor antagonist (IL-1RA) in the postmortem brain tissues of prefrontal and parietal cortex, putamen, and hypothalamus. Both protein and mRNA levels of IL-1RA were specifically decreased in the prefrontal cortex of schizophrenic patients, whereas IL-1beta levels were not significantly altered in all the regions examined. The IL-1RA decrease was not correlated with the dose of antipsychotics given to patients. There was no influence of this illness on protein levels for IL-1 receptor type 1 in the prefrontal cortex, either. In contrast, IL-1RA serum levels were increased in schizophrenic patients, especially in drug-free patients, as reported previously. These findings suggest that chronic schizophrenia down-regulates IL-1RA production the prefrontal cortex, irrespective of its impact on the periphery. IL-1RA reduction might reflect an immunopathologic trait of the prefrontal region in schizophrenic patients."xsd:string |
| http://purl.uniprot.org/citations/12804791 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0168-0102(03)00093-2"xsd:string |
| http://purl.uniprot.org/citations/12804791 | http://purl.uniprot.org/core/author | "Nakamura R."xsd:string |
| http://purl.uniprot.org/citations/12804791 | http://purl.uniprot.org/core/author | "Takahashi H."xsd:string |
| http://purl.uniprot.org/citations/12804791 | http://purl.uniprot.org/core/author | "Watanabe Y."xsd:string |
| http://purl.uniprot.org/citations/12804791 | http://purl.uniprot.org/core/author | "Toyooka K."xsd:string |
| http://purl.uniprot.org/citations/12804791 | http://purl.uniprot.org/core/author | "Makifuchi T."xsd:string |
| http://purl.uniprot.org/citations/12804791 | http://purl.uniprot.org/core/author | "Iritani S."xsd:string |
| http://purl.uniprot.org/citations/12804791 | http://purl.uniprot.org/core/author | "Shimizu E."xsd:string |
| http://purl.uniprot.org/citations/12804791 | http://purl.uniprot.org/core/author | "Kakita A."xsd:string |
| http://purl.uniprot.org/citations/12804791 | http://purl.uniprot.org/core/author | "Nawa H."xsd:string |
| http://purl.uniprot.org/citations/12804791 | http://purl.uniprot.org/core/author | "Someya T."xsd:string |
| http://purl.uniprot.org/citations/12804791 | http://purl.uniprot.org/core/author | "Iyo M."xsd:string |
| http://purl.uniprot.org/citations/12804791 | http://purl.uniprot.org/core/author | "Asama K."xsd:string |
| http://purl.uniprot.org/citations/12804791 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12804791 | http://purl.uniprot.org/core/name | "Neurosci Res"xsd:string |
| http://purl.uniprot.org/citations/12804791 | http://purl.uniprot.org/core/pages | "299-307"xsd:string |
| http://purl.uniprot.org/citations/12804791 | http://purl.uniprot.org/core/title | "A decrease in interleukin-1 receptor antagonist expression in the prefrontal cortex of schizophrenic patients."xsd:string |
| http://purl.uniprot.org/citations/12804791 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/12804791 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12804791 |
| http://purl.uniprot.org/citations/12804791 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12804791 |
| http://purl.uniprot.org/uniprot/#_B8ZZW4-mappedCitation-12804791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12804791 |
| http://purl.uniprot.org/uniprot/#_P14778-mappedCitation-12804791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12804791 |
| http://purl.uniprot.org/uniprot/#_Q6NWP5-mappedCitation-12804791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12804791 |