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http://purl.uniprot.org/citations/12805332http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12805332http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

We examined the relationship between a mutant (T) for wild-type (C) allele substitution of the human kallikrein-2 gene (KLK2), circulating human kallikrein-2 (hK2) levels and prostate cancer risk.

Patients and methods

We studied 1,287 consecutive men who underwent prostate biopsies because of an abnormal prostate-specific antigen level. Serum and DNA were obtained before biopsy. Cases were patients with cancer, and controls were patients with no cancer. The mutant and wild-type alleles of the KLK2 gene were designated as the T and C alleles, respectively.

Results

Of the 1,287 men, 616 had cancer, and 671 had no cancer. The overall distribution of the CC, CT, and TT KLK2 genotypes was 55.1%, 38.2%, and 6.8%, respectively. The median hK2 levels for men with the CC, CT, and TT genotypes were 0.24, 0.18, and 0.062 ng/mL and correlated with the genotypes, respectively (P =.0001). The adjusted odds ratios for prostate cancer for patients with the TT and CT genotypes compared with patients with the CC genotype, were 2.13 (95% confidence interval [CI], 1.3 to 3.5; P =.004) and 1.51 (95% CI, 1.2 to 2.0; P =.002), respectively. The adjusted odds ratio for prostate cancer for patients in the fourth quartile of hK2 compared with the first quartile was 4.33 (95% CI, 2.9 to 6.4; P =.0001). When combined, the adjusted odds ratio for having prostate cancer was 13.92 (95% CI, 6.6 to 29.2; P =.0001) for patients with high hK2 levels and at least one T allele.

Conclusion

The C/T polymorphism of the KLK2 gene and circulating levels of hK2 are correlated and, in combination, are highly predictive for prostate cancer."xsd:string
http://purl.uniprot.org/citations/12805332http://purl.org/dc/terms/identifier"doi:10.1200/jco.2003.11.007"xsd:string
http://purl.uniprot.org/citations/12805332http://purl.uniprot.org/core/author"Zhang W.W."xsd:string
http://purl.uniprot.org/citations/12805332http://purl.uniprot.org/core/author"Ho M."xsd:string
http://purl.uniprot.org/citations/12805332http://purl.uniprot.org/core/author"Jewett M.A."xsd:string
http://purl.uniprot.org/citations/12805332http://purl.uniprot.org/core/author"Emami M."xsd:string
http://purl.uniprot.org/citations/12805332http://purl.uniprot.org/core/author"Narod S.A."xsd:string
http://purl.uniprot.org/citations/12805332http://purl.uniprot.org/core/author"Evans A."xsd:string
http://purl.uniprot.org/citations/12805332http://purl.uniprot.org/core/author"Toi A."xsd:string
http://purl.uniprot.org/citations/12805332http://purl.uniprot.org/core/author"Nam R.K."xsd:string
http://purl.uniprot.org/citations/12805332http://purl.uniprot.org/core/author"Sweet J."xsd:string
http://purl.uniprot.org/citations/12805332http://purl.uniprot.org/core/author"Trachtenberg J."xsd:string
http://purl.uniprot.org/citations/12805332http://purl.uniprot.org/core/author"Diamandis E."xsd:string
http://purl.uniprot.org/citations/12805332http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12805332http://purl.uniprot.org/core/name"J Clin Oncol"xsd:string
http://purl.uniprot.org/citations/12805332http://purl.uniprot.org/core/pages"2312-2319"xsd:string
http://purl.uniprot.org/citations/12805332http://purl.uniprot.org/core/title"Single nucleotide polymorphism of the human kallikrein-2 gene highly correlates with serum human kallikrein-2 levels and in combination enhances prostate cancer detection."xsd:string
http://purl.uniprot.org/citations/12805332http://purl.uniprot.org/core/volume"21"xsd:string
http://purl.uniprot.org/citations/12805332http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12805332
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