| http://purl.uniprot.org/citations/12808046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12808046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12808046 | http://www.w3.org/2000/01/rdf-schema#comment | "To further understand the assembly and maintenance of the muscle contractile apparatus, we have identified a new protein, UNC-98, in the muscle of Caenorhabditis elegans. unc-98 mutants display reduced motility and a characteristic defect in muscle structure. We show that the major defect in the mutant muscle is in the M-lines and dense bodies (Z-line analogs). Both functionally and compositionally, nematode M-lines and dense bodies are analogous to focal adhesions of nonmuscle cells. UNC-98 is a novel 310-residue polypeptide consisting of four C2H2 Zn fingers and several possible nuclear localization signal and nuclear export signal sequences. By use of UNC-98 antibodies and green fluorescent protein fusions (to full-length UNC-98 and UNC-98 fragments), we have shown that UNC-98 resides at M-lines, muscle cell nuclei, and possibly at dense bodies. Furthermore, we demonstrated that 1) the N-terminal 106 amino acids are both necessary and sufficient for nuclear localization, and 2) the C-terminal (fourth) Zn finger is required for localization to M-lines and dense bodies. UNC-98 interacts with UNC-97, a C. elegans homolog of PINCH. We propose that UNC-98 is both a structural component of muscle focal adhesions and a nuclear protein that influences gene expression."xsd:string |
| http://purl.uniprot.org/citations/12808046 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e02-10-0676"xsd:string |
| http://purl.uniprot.org/citations/12808046 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e02-10-0676"xsd:string |
| http://purl.uniprot.org/citations/12808046 | http://purl.uniprot.org/core/author | "Qadota H."xsd:string |
| http://purl.uniprot.org/citations/12808046 | http://purl.uniprot.org/core/author | "Qadota H."xsd:string |
| http://purl.uniprot.org/citations/12808046 | http://purl.uniprot.org/core/author | "Benian G.M."xsd:string |
| http://purl.uniprot.org/citations/12808046 | http://purl.uniprot.org/core/author | "Benian G.M."xsd:string |
| http://purl.uniprot.org/citations/12808046 | http://purl.uniprot.org/core/author | "Moerman D.G."xsd:string |
| http://purl.uniprot.org/citations/12808046 | http://purl.uniprot.org/core/author | "Moerman D.G."xsd:string |
| http://purl.uniprot.org/citations/12808046 | http://purl.uniprot.org/core/author | "Miller R.K."xsd:string |
| http://purl.uniprot.org/citations/12808046 | http://purl.uniprot.org/core/author | "Miller R.K."xsd:string |
| http://purl.uniprot.org/citations/12808046 | http://purl.uniprot.org/core/author | "Flaherty D.B."xsd:string |
| http://purl.uniprot.org/citations/12808046 | http://purl.uniprot.org/core/author | "Flaherty D.B."xsd:string |
| http://purl.uniprot.org/citations/12808046 | http://purl.uniprot.org/core/author | "Mercer K.B."xsd:string |
| http://purl.uniprot.org/citations/12808046 | http://purl.uniprot.org/core/author | "Mercer K.B."xsd:string |
| http://purl.uniprot.org/citations/12808046 | http://purl.uniprot.org/core/author | "Tinley T.L."xsd:string |
| http://purl.uniprot.org/citations/12808046 | http://purl.uniprot.org/core/author | "Tinley T.L."xsd:string |
| http://purl.uniprot.org/citations/12808046 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12808046 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12808046 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/12808046 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/12808046 | http://purl.uniprot.org/core/pages | "2492-2507"xsd:string |
| http://purl.uniprot.org/citations/12808046 | http://purl.uniprot.org/core/pages | "2492-2507"xsd:string |