| http://purl.uniprot.org/citations/1280821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1280821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1280821 | http://www.w3.org/2000/01/rdf-schema#comment | "T lymphocytes are activated by interactions with antigens, lymphokines, and cell adhesion molecules. Tyrosine phosphorylation has been implicated as important in signaling through each of these pathways, but except for p56lck, a member of the Src family that associates with CD4 and CD8, the protein-tyrosine kinases involved have not been defined. We describe here a tyrosine kinase gene that we have designated itk (for IL-2-inducible T-cell kinase). The itk gene specifies a 72-kDa protein-tyrosine kinase that is related to members of the Src family but lacks two features characteristic of Src kinases: an N-terminal myristoylation consensus sequence and a regulatory tyrosine residue near the C terminus. Analysis of mouse tissues and cell lines indicates that itk is specifically expressed in the T-cell lineage, suggesting that the tyrosine kinase encoded by itk functions in a signal transduction pathway unique to T lymphocytes. On addition of IL-2 to responsive T cells, itk RNA increases in parallel with that of IL-2R alpha, implicating itk in T-cell activation."xsd:string |
| http://purl.uniprot.org/citations/1280821 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.89.23.11194"xsd:string |
| http://purl.uniprot.org/citations/1280821 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.89.23.11194"xsd:string |
| http://purl.uniprot.org/citations/1280821 | http://purl.uniprot.org/core/author | "Siliciano J.D."xsd:string |
| http://purl.uniprot.org/citations/1280821 | http://purl.uniprot.org/core/author | "Siliciano J.D."xsd:string |
| http://purl.uniprot.org/citations/1280821 | http://purl.uniprot.org/core/author | "Desiderio S.V."xsd:string |
| http://purl.uniprot.org/citations/1280821 | http://purl.uniprot.org/core/author | "Desiderio S.V."xsd:string |
| http://purl.uniprot.org/citations/1280821 | http://purl.uniprot.org/core/author | "Morrow T.A."xsd:string |
| http://purl.uniprot.org/citations/1280821 | http://purl.uniprot.org/core/author | "Morrow T.A."xsd:string |
| http://purl.uniprot.org/citations/1280821 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1280821 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1280821 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/1280821 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/1280821 | http://purl.uniprot.org/core/pages | "11194-11198"xsd:string |
| http://purl.uniprot.org/citations/1280821 | http://purl.uniprot.org/core/pages | "11194-11198"xsd:string |
| http://purl.uniprot.org/citations/1280821 | http://purl.uniprot.org/core/title | "itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2."xsd:string |
| http://purl.uniprot.org/citations/1280821 | http://purl.uniprot.org/core/title | "itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2."xsd:string |
| http://purl.uniprot.org/citations/1280821 | http://purl.uniprot.org/core/volume | "89"xsd:string |
| http://purl.uniprot.org/citations/1280821 | http://purl.uniprot.org/core/volume | "89"xsd:string |
| http://purl.uniprot.org/citations/1280821 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1280821 |
| http://purl.uniprot.org/citations/1280821 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1280821 |
| http://purl.uniprot.org/citations/1280821 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1280821 |
| http://purl.uniprot.org/citations/1280821 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1280821 |