| http://purl.uniprot.org/citations/1280823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1280823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1280823 | http://www.w3.org/2000/01/rdf-schema#comment | "src homology 2 (SH2) domains direct binding to specific phosphotyrosyl proteins. Recently, SH2-containing protein-tyrosine-phosphatases (PTPs) were identified. Using degenerate oligonucleotides and the PCR, we have cloned a cDNA for an additional PTP, SH-PTP2, which contains two SH2 domains and is expressed ubiquitously. When expressed in Escherichia coli, SH-PTP2 displays tyrosine-specific phosphatase activity. Strong sequence similarity between SH-PTP2 and the Drosophila gene corkscrew (csw) and their similar patterns of expression suggest that SH-PTP2 is the human corkscrew homolog. Sequence comparisons between SH-PTP2, SH-PTP1, corkscrew, and other SH2-containing proteins suggest the existence of a subfamily of SH2 domains found specifically in PTPs, whereas comparison of the PTP domains of the SH2-containing PTPs with other tyrosine phosphatases suggests the existence of a subfamily of PTPs containing SH2 domains. Since corkscrew, a member of the terminal class signal transduction pathway, acts in concert with D-raf to positively transduce the signal generated by the receptor tyrosine kinase torso, these findings suggest several mechanisms by which SH-PTP2 may participate in mammalian signal transduction."xsd:string |
| http://purl.uniprot.org/citations/1280823 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.89.23.11239"xsd:string |
| http://purl.uniprot.org/citations/1280823 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.89.23.11239"xsd:string |
| http://purl.uniprot.org/citations/1280823 | http://purl.uniprot.org/core/author | "Neel B.G."xsd:string |
| http://purl.uniprot.org/citations/1280823 | http://purl.uniprot.org/core/author | "Neel B.G."xsd:string |
| http://purl.uniprot.org/citations/1280823 | http://purl.uniprot.org/core/author | "Plutzky J."xsd:string |
| http://purl.uniprot.org/citations/1280823 | http://purl.uniprot.org/core/author | "Plutzky J."xsd:string |
| http://purl.uniprot.org/citations/1280823 | http://purl.uniprot.org/core/author | "Freeman R.M. Jr."xsd:string |
| http://purl.uniprot.org/citations/1280823 | http://purl.uniprot.org/core/author | "Freeman R.M. Jr."xsd:string |
| http://purl.uniprot.org/citations/1280823 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1280823 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1280823 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/1280823 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/1280823 | http://purl.uniprot.org/core/pages | "11239-11243"xsd:string |
| http://purl.uniprot.org/citations/1280823 | http://purl.uniprot.org/core/pages | "11239-11243"xsd:string |
| http://purl.uniprot.org/citations/1280823 | http://purl.uniprot.org/core/title | "Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew."xsd:string |
| http://purl.uniprot.org/citations/1280823 | http://purl.uniprot.org/core/title | "Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew."xsd:string |
| http://purl.uniprot.org/citations/1280823 | http://purl.uniprot.org/core/volume | "89"xsd:string |
| http://purl.uniprot.org/citations/1280823 | http://purl.uniprot.org/core/volume | "89"xsd:string |
| http://purl.uniprot.org/citations/1280823 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1280823 |
| http://purl.uniprot.org/citations/1280823 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1280823 |
| http://purl.uniprot.org/citations/1280823 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1280823 |
| http://purl.uniprot.org/citations/1280823 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1280823 |