| http://purl.uniprot.org/citations/12808450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12808450 | http://www.w3.org/2000/01/rdf-schema#comment | "Amyloid-beta peptide (Abeta) interacts with the vasculature to influence Abeta levels in the brain and cerebral blood flow, providing a means of amplifying the Abeta-induced cellular stress underlying neuronal dysfunction and dementia. Systemic Abeta infusion and studies in genetically manipulated mice show that Abeta interaction with receptor for advanced glycation end products (RAGE)-bearing cells in the vessel wall results in transport of Abeta across the blood-brain barrier (BBB) and expression of proinflammatory cytokines and endothelin-1 (ET-1), the latter mediating Abeta-induced vasoconstriction. Inhibition of RAGE-ligand interaction suppresses accumulation of Abeta in brain parenchyma in a mouse transgenic model. These findings suggest that vascular RAGE is a target for inhibiting pathogenic consequences of Abeta-vascular interactions, including development of cerebral amyloidosis."xsd:string |
| http://purl.uniprot.org/citations/12808450 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm890"xsd:string |
| http://purl.uniprot.org/citations/12808450 | http://purl.uniprot.org/core/author | "Frangione B."xsd:string |
| http://purl.uniprot.org/citations/12808450 | http://purl.uniprot.org/core/author | "Lin C."xsd:string |
| http://purl.uniprot.org/citations/12808450 | http://purl.uniprot.org/core/author | "Yu J."xsd:string |
| http://purl.uniprot.org/citations/12808450 | http://purl.uniprot.org/core/author | "Zhu H."xsd:string |
| http://purl.uniprot.org/citations/12808450 | http://purl.uniprot.org/core/author | "Ghiso J."xsd:string |
| http://purl.uniprot.org/citations/12808450 | http://purl.uniprot.org/core/author | "Stern D."xsd:string |
| http://purl.uniprot.org/citations/12808450 | http://purl.uniprot.org/core/author | "Zlokovic B."xsd:string |
| http://purl.uniprot.org/citations/12808450 | http://purl.uniprot.org/core/author | "Arnold B."xsd:string |
| http://purl.uniprot.org/citations/12808450 | http://purl.uniprot.org/core/author | "Stern A."xsd:string |
| http://purl.uniprot.org/citations/12808450 | http://purl.uniprot.org/core/author | "Schmidt A.M."xsd:string |
| http://purl.uniprot.org/citations/12808450 | http://purl.uniprot.org/core/author | "Jovanovic S."xsd:string |
| http://purl.uniprot.org/citations/12808450 | http://purl.uniprot.org/core/author | "Deane R."xsd:string |
| http://purl.uniprot.org/citations/12808450 | http://purl.uniprot.org/core/author | "Armstrong D.L."xsd:string |
| http://purl.uniprot.org/citations/12808450 | http://purl.uniprot.org/core/author | "Welch D."xsd:string |
| http://purl.uniprot.org/citations/12808450 | http://purl.uniprot.org/core/author | "Liliensiek B."xsd:string |
| http://purl.uniprot.org/citations/12808450 | http://purl.uniprot.org/core/author | "Nawroth P."xsd:string |
| http://purl.uniprot.org/citations/12808450 | http://purl.uniprot.org/core/author | "Hofman F."xsd:string |
| http://purl.uniprot.org/citations/12808450 | http://purl.uniprot.org/core/author | "LaRue B."xsd:string |
| http://purl.uniprot.org/citations/12808450 | http://purl.uniprot.org/core/author | "Hogg E."xsd:string |
| http://purl.uniprot.org/citations/12808450 | http://purl.uniprot.org/core/author | "Du Yan S."xsd:string |
| http://purl.uniprot.org/citations/12808450 | http://purl.uniprot.org/core/author | "Kindy M."xsd:string |
| http://purl.uniprot.org/citations/12808450 | http://purl.uniprot.org/core/author | "Manness L."xsd:string |