| http://purl.uniprot.org/citations/12809504 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12809504 | http://www.w3.org/2000/01/rdf-schema#comment | "Serum response factor (SRF) is a phosphoprotein that regulates skeletal and cardiac alpha-actin gene transcription. Myotonic dystrophy protein kinase (DMPK), a muscle- and neuron-restricted kinase, enhanced SRF-mediated promoter activity of the skeletal and cardiac alpha-actin genes in C2C12 myoblasts as well as in nonmyogenic cells. DMPK phosphorylated SRF in vitro in the alphaI coil of the DNA-binding domain in the MADS box, a highly conserved region required for DNA binding, dimerization, and co-activator interaction in COS and CV1 cells. Threonine 159 in the MADS box alphaI coil was a specific phosphorylation target in vitro as well as in vivo of both DMPK and protein kinase C-alpha. Substitution of threonine 159 with the nonphosphorylatable residue alanine markedly diminished activation of the cardiac alpha-actin promoter in the presence of kinase, while its substitution with aspartic acid, to introduce a negative charge and mimic phosphorylation, restored activation completely. Phosphorylation of the MADS box may constitute a novel mechanism for regulation of SRF-dependent actin gene transcription."xsd:string |
| http://purl.uniprot.org/citations/12809504 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi030045n"xsd:string |
| http://purl.uniprot.org/citations/12809504 | http://purl.uniprot.org/core/author | "Wei L."xsd:string |
| http://purl.uniprot.org/citations/12809504 | http://purl.uniprot.org/core/author | "Schwartz R.J."xsd:string |
| http://purl.uniprot.org/citations/12809504 | http://purl.uniprot.org/core/author | "Weigel N.L."xsd:string |
| http://purl.uniprot.org/citations/12809504 | http://purl.uniprot.org/core/author | "Epstein H.F."xsd:string |
| http://purl.uniprot.org/citations/12809504 | http://purl.uniprot.org/core/author | "Rowan B.G."xsd:string |
| http://purl.uniprot.org/citations/12809504 | http://purl.uniprot.org/core/author | "Balasubramanyam A."xsd:string |
| http://purl.uniprot.org/citations/12809504 | http://purl.uniprot.org/core/author | "Booth F.W."xsd:string |
| http://purl.uniprot.org/citations/12809504 | http://purl.uniprot.org/core/author | "Fluck M."xsd:string |
| http://purl.uniprot.org/citations/12809504 | http://purl.uniprot.org/core/author | "Belaguli N."xsd:string |
| http://purl.uniprot.org/citations/12809504 | http://purl.uniprot.org/core/author | "Iyer D."xsd:string |
| http://purl.uniprot.org/citations/12809504 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12809504 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/12809504 | http://purl.uniprot.org/core/pages | "7477-7486"xsd:string |
| http://purl.uniprot.org/citations/12809504 | http://purl.uniprot.org/core/title | "Novel phosphorylation target in the serum response factor MADS box regulates alpha-actin transcription."xsd:string |
| http://purl.uniprot.org/citations/12809504 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/12809504 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12809504 |
| http://purl.uniprot.org/citations/12809504 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12809504 |
| http://purl.uniprot.org/uniprot/#_P11831-mappedCitation-12809504 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12809504 |
| http://purl.uniprot.org/uniprot/P11831 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12809504 |