| http://purl.uniprot.org/citations/12810063 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12810063 | http://www.w3.org/2000/01/rdf-schema#comment | "The neuronal alpha7 nicotinic acetylcholine (ACh) receptor is believed to be a highly Ca(2+) permeable ligand-gated receptor-channel. However, the contribution of Ca(2+) to cationic current generated by ACh has not yet been directly measured to date. Simultaneous fluorescence and whole-cell current measurements using the Ca(2+) indicator dye fura-2 were made in GH4C1 pituitary cells stably expressing human alpha7 receptors and the fractional Ca(2+) current (the proportion of whole-cell current carried by Ca(2+); P(f)) was determined. We report that the P(f) value was 11.4+/-1.3%. This value was significantly larger than P(f) of human L248Talpha7 receptor mutant (P(f)=6.3+/-1.0%) and of rat alpha7 receptor (P(f)=8.8+/-1.5%) both determined in transiently transfected GH4C1 cells. In our knowledge, the findings here reported indicate the human alpha7 receptors are the most Ca(2+) conductive homomeric ligand-gated receptor-channels expressed in a heterologous cell system."xsd:string |
| http://purl.uniprot.org/citations/12810063 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0143-4160(03)00071-x"xsd:string |
| http://purl.uniprot.org/citations/12810063 | http://purl.uniprot.org/core/author | "Eusebi F."xsd:string |
| http://purl.uniprot.org/citations/12810063 | http://purl.uniprot.org/core/author | "Renzi M."xsd:string |
| http://purl.uniprot.org/citations/12810063 | http://purl.uniprot.org/core/author | "Fucile S."xsd:string |
| http://purl.uniprot.org/citations/12810063 | http://purl.uniprot.org/core/author | "Lax P."xsd:string |
| http://purl.uniprot.org/citations/12810063 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12810063 | http://purl.uniprot.org/core/name | "Cell Calcium"xsd:string |
| http://purl.uniprot.org/citations/12810063 | http://purl.uniprot.org/core/pages | "205-209"xsd:string |
| http://purl.uniprot.org/citations/12810063 | http://purl.uniprot.org/core/title | "Fractional Ca(2+) current through human neuronal alpha7 nicotinic acetylcholine receptors."xsd:string |
| http://purl.uniprot.org/citations/12810063 | http://purl.uniprot.org/core/volume | "34"xsd:string |
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