| http://purl.uniprot.org/citations/12810089 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12810089 | http://www.w3.org/2000/01/rdf-schema#comment | "We had previously reported that activation of histamine H(3)-receptors (H(3)R) on cardiac adrenergic nerve terminals decreases norepinephrine (NE) overflow from ischemic hearts and alleviates reperfusion arrhythmias. Thus, we used transgenic mice lacking H(3)R (H(3)R(-/-)) to investigate whether ischemic arrhythmias might be more severe in H(3)R(-/-) hearts than in hearts with intact H(3)R (H(3)R(+/+)). We report a greater incidence and longer duration of ventricular fibrillation (VF) in H(3)R(-/-) hearts subjected to ischemia. VF duration was linearly correlated with NE overflow, suggesting a possible cause-effect relationship between magnitude of NE release and severity of reperfusion arrhythmias. Thus, our findings strengthen a protective antiarrhythmic role of H(3)R in myocardial ischemia. Since malignant tachyarrhythmias cause sudden death in ischemic heart disease, attenuation of NE release by selective H(3)R agonists may represent a new approach in the prevention and treatment of ischemic arrhythmias."xsd:string |
| http://purl.uniprot.org/citations/12810089 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(03)01010-6"xsd:string |
| http://purl.uniprot.org/citations/12810089 | http://purl.uniprot.org/core/author | "Koyama M."xsd:string |
| http://purl.uniprot.org/citations/12810089 | http://purl.uniprot.org/core/author | "Levi R."xsd:string |
| http://purl.uniprot.org/citations/12810089 | http://purl.uniprot.org/core/author | "Heerdt P.M."xsd:string |
| http://purl.uniprot.org/citations/12810089 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12810089 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/12810089 | http://purl.uniprot.org/core/pages | "792-796"xsd:string |
| http://purl.uniprot.org/citations/12810089 | http://purl.uniprot.org/core/title | "Increased severity of reperfusion arrhythmias in mouse hearts lacking histamine H3-receptors."xsd:string |
| http://purl.uniprot.org/citations/12810089 | http://purl.uniprot.org/core/volume | "306"xsd:string |
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