| http://purl.uniprot.org/citations/12810822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12810822 | http://www.w3.org/2000/01/rdf-schema#comment | "Sphingolipid activator proteins (saposins A, B, C, and D) are derived from a common precursor protein (prosaposin) and specifically activate in vivo degradation of glycolipids with short carbohydrate chains. A mouse model of prosaposin deficiency (prosaposin-/-) closely mimics the human disease with an elevation of multiple glycolipids. The recently developed saposin A-/-mice showed a chronic form of globoid cell leukodystrophy, establishing the essential in vivo role of saposin A as an activator for galactosylceramidase to degrade galactosylceramide. Seminolipid, the principal glycolipid in spermatozoa, and its precursor/degradative product, galactosylalkylacylglycerol (GalEAG), were analyzed in the testis of the two mouse mutants by electrospray ionization mass spectrometry. Saposin A-/-mice showed the normal seminolipid level, while that of prosaposin-/-mice was approximately 150% of the normal level at the terminal stage. In contrast, GalEAG increased up to 10 times in saposin A-/-mice, whereas it decreased with age in the wild-type as well as in prosaposin-/-mice. These analytical findings on the two saposin mutants may shed some light on the physiological function of seminolipid and GalEAG."xsd:string |
| http://purl.uniprot.org/citations/12810822 | http://purl.org/dc/terms/identifier | "doi:10.1194/jlr.m300119-jlr200"xsd:string |
| http://purl.uniprot.org/citations/12810822 | http://purl.uniprot.org/core/author | "Suzuki K."xsd:string |
| http://purl.uniprot.org/citations/12810822 | http://purl.uniprot.org/core/author | "Fujimoto H."xsd:string |
| http://purl.uniprot.org/citations/12810822 | http://purl.uniprot.org/core/author | "Matsuda J."xsd:string |
| http://purl.uniprot.org/citations/12810822 | http://purl.uniprot.org/core/author | "Ishizuka I."xsd:string |
| http://purl.uniprot.org/citations/12810822 | http://purl.uniprot.org/core/author | "Tadano-Aritomi K."xsd:string |
| http://purl.uniprot.org/citations/12810822 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12810822 | http://purl.uniprot.org/core/name | "J Lipid Res"xsd:string |
| http://purl.uniprot.org/citations/12810822 | http://purl.uniprot.org/core/pages | "1737-1743"xsd:string |
| http://purl.uniprot.org/citations/12810822 | http://purl.uniprot.org/core/title | "Seminolipid and its precursor/degradative product, galactosylalkylacylglycerol, in the testis of saposin A- and prosaposin-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/12810822 | http://purl.uniprot.org/core/volume | "44"xsd:string |
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