| http://purl.uniprot.org/citations/12814803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12814803 | http://www.w3.org/2000/01/rdf-schema#comment | "The 70 kDa heat-shock protein (Hsp70) exhibits a broad range of chaperone functions that respond both to internal and external stresses, and its heat-induced expression both declines with age and reduces age-specific mortality rates. Here we test for changes in both longevity and the level of Hsp70-induced expression as correlated responses to selection on both heat-stress resistance and longevity in D. melanogaster. Three replicated H lines were heat-stress selected and compared to their respective non-selected controls (C lines) in the 25th generation of heat-stress selection. The direct response in heat-stress resistance was 56% in males and 38% in females. Heat-stress selection improved longevity in males at normal temperatures. All lines were subsequently subjected to one generation of truncation selection on longevity (selection intensity, i=1.28 for H lines and 1.36 for C lines). The heat-induced Hsp70 expression seems to increase very weakly by heat-stress selection but shows a dramatic and persistent decline by selecting for long-lived flies. A mechanism of longevity selection, involving changes in Hsp70 regulation, is suggested."xsd:string |
| http://purl.uniprot.org/citations/12814803 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0531-5565(03)00057-3"xsd:string |
| http://purl.uniprot.org/citations/12814803 | http://purl.uniprot.org/core/author | "Loeschcke V."xsd:string |
| http://purl.uniprot.org/citations/12814803 | http://purl.uniprot.org/core/author | "Norry F.M."xsd:string |
| http://purl.uniprot.org/citations/12814803 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12814803 | http://purl.uniprot.org/core/name | "Exp Gerontol"xsd:string |
| http://purl.uniprot.org/citations/12814803 | http://purl.uniprot.org/core/pages | "673-681"xsd:string |
| http://purl.uniprot.org/citations/12814803 | http://purl.uniprot.org/core/title | "Heat-induced expression of a molecular chaperone decreases by selecting for long-lived individuals."xsd:string |
| http://purl.uniprot.org/citations/12814803 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/12814803 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12814803 |
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| http://purl.uniprot.org/uniprot/#_Q9BIR7-mappedCitation-12814803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12814803 |
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| http://purl.uniprot.org/uniprot/P82910 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12814803 |
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| http://purl.uniprot.org/uniprot/Q9VG58 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12814803 |
| http://purl.uniprot.org/uniprot/P02825 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12814803 |
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| http://purl.uniprot.org/uniprot/Q9BIR7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12814803 |