| http://purl.uniprot.org/citations/12815042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12815042 | http://www.w3.org/2000/01/rdf-schema#comment | "Smads proteins play a key role in the intracellular signaling of the transforming growth factor (TGF)-beta family of growth factors, which exhibits a diverse set of cellular responses, including cell proliferation and differentiation. In particular, Smad7 acts as an antagonist of TGF-beta signaling, which could determine the intensity or duration of its signaling cascade. In this study we identified a protein inhibitor of activated STAT (signal transducers and activators of transcription), PIASy, as a novel interaction partner of Smad7 by yeast two-hybrid screening using the MH2 domain of Smad7 as bait. The association of Smad7 and PIASy was confirmed using co-expressed tagged proteins in 293T cells. Moreover, we found that other Smads including Smad3 also associated with PIASy through its MH2 domain, and PIASy suppressed TGF-beta-mediated activation of Smad3. PIASy also stimulated the sumoylation of Smad3 in vivo. Furthermore, endogenous PIASy expression was induced by TGF-beta in Hep3B cells. These findings provide the first evidence that a PIAS family protein, PIASy, associates with Smads and involves the regulation of TGF-beta signaling using the negative feedback loop."xsd:string |
| http://purl.uniprot.org/citations/12815042 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m304961200"xsd:string |
| http://purl.uniprot.org/citations/12815042 | http://purl.uniprot.org/core/author | "Sato N."xsd:string |
| http://purl.uniprot.org/citations/12815042 | http://purl.uniprot.org/core/author | "Sugiyama K."xsd:string |
| http://purl.uniprot.org/citations/12815042 | http://purl.uniprot.org/core/author | "Yamamoto T."xsd:string |
| http://purl.uniprot.org/citations/12815042 | http://purl.uniprot.org/core/author | "Matsuda T."xsd:string |
| http://purl.uniprot.org/citations/12815042 | http://purl.uniprot.org/core/author | "Muromoto R."xsd:string |
| http://purl.uniprot.org/citations/12815042 | http://purl.uniprot.org/core/author | "Imoto S."xsd:string |
| http://purl.uniprot.org/citations/12815042 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12815042 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12815042 | http://purl.uniprot.org/core/pages | "34253-34258"xsd:string |
| http://purl.uniprot.org/citations/12815042 | http://purl.uniprot.org/core/title | "Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3."xsd:string |
| http://purl.uniprot.org/citations/12815042 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12815042 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12815042 |
| http://purl.uniprot.org/citations/12815042 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12815042 |
| http://purl.uniprot.org/uniprot/#_A0A078BBI5-mappedCitation-12815042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12815042 |
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