| http://purl.uniprot.org/citations/12815055 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12815055 | http://www.w3.org/2000/01/rdf-schema#comment | "A novel potassium channel antagonist has been purified from the defensive mucus secreted by Calliostoma canaliculatum, a marine snail found in the temperate coastal waters of the western Pacific. The toxin is expelled from the hypobranchial gland as part of a defensive response and is contained within a viscous matrix that minimizes dilution and degradation. The active compound was isolated by multistage microbore HPLC separations followed by bioactivity assays. Nuclear magnetic resonance, combined with electrospray ionization Fourier-transform ion cyclotron resonance and electrospray ionization ion trap mass spectrometry indicate that the active component is a heretofore unknown indole-derivative, a disulfide-linked dimer of 6-bromo-2-mercaptotryptamine (BrMT). Exudates from the hypobranchial glands of various marine mollusks have been sources for dye compounds such as 6-6 dibromoindigo, the ancient dye Tyrian purple. BrMT represents the first correlation of a hypobranchial gland exudate with a molecular response. Voltage clamp experiments with a number of K channel subtypes indicate that BrMT inhibits certain voltage-gated K channels of the Kv1 subfamily."xsd:string |
| http://purl.uniprot.org/citations/12815055 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m301271200"xsd:string |
| http://purl.uniprot.org/citations/12815055 | http://purl.uniprot.org/core/author | "Williams E.R."xsd:string |
| http://purl.uniprot.org/citations/12815055 | http://purl.uniprot.org/core/author | "Sweedler J.V."xsd:string |
| http://purl.uniprot.org/citations/12815055 | http://purl.uniprot.org/core/author | "Gilly W.F."xsd:string |
| http://purl.uniprot.org/citations/12815055 | http://purl.uniprot.org/core/author | "Kelley W.P."xsd:string |
| http://purl.uniprot.org/citations/12815055 | http://purl.uniprot.org/core/author | "Jockusch R.A."xsd:string |
| http://purl.uniprot.org/citations/12815055 | http://purl.uniprot.org/core/author | "Sack J.T."xsd:string |
| http://purl.uniprot.org/citations/12815055 | http://purl.uniprot.org/core/author | "Wolters A.M."xsd:string |
| http://purl.uniprot.org/citations/12815055 | http://purl.uniprot.org/core/author | "Jurchen J.C."xsd:string |
| http://purl.uniprot.org/citations/12815055 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12815055 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12815055 | http://purl.uniprot.org/core/pages | "34934-34942"xsd:string |
| http://purl.uniprot.org/citations/12815055 | http://purl.uniprot.org/core/title | "Characterization of a novel gastropod toxin (6-bromo-2-mercaptotryptamine) that inhibits shaker K channel activity."xsd:string |
| http://purl.uniprot.org/citations/12815055 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12815055 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12815055 |
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