| http://purl.uniprot.org/citations/12815436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12815436 | http://www.w3.org/2000/01/rdf-schema#comment | "To maintain genome stability, DNA replication is strictly regulated to occur only once per cell cycle. In eukaryotes, the presence of 'licensing proteins' at replication origins during the G1 cell-cycle phase allows the formation of the pre-replicative complex. The removal of licensing proteins from chromatin during the S phase ensures that origins fire only once per cell cycle. Here we show that the CUL-4 ubiquitin ligase temporally restricts DNA-replication licensing in Caenorhabditis elegans. Inactivation of CUL-4 causes massive DNA re-replication, producing cells with up to 100C DNA content. The C. elegans orthologue of the replication-licensing factor Cdt1 (refs 2, 3) is required for DNA replication. C. elegans CDT-1 is present in G1-phase nuclei but disappears as cells enter S phase. In cells lacking CUL-4, CDT-1 levels fail to decrease during S phase and instead remain constant in the re-replicating cells. Removal of one genomic copy of cdt-1 suppresses the cul-4 re-replication phenotype. We propose that CUL-4 prevents aberrant re-initiation of DNA replication, at least in part, by facilitating the degradation of CDT-1."xsd:string |
| http://purl.uniprot.org/citations/12815436 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature01747"xsd:string |
| http://purl.uniprot.org/citations/12815436 | http://purl.uniprot.org/core/author | "Feng H."xsd:string |
| http://purl.uniprot.org/citations/12815436 | http://purl.uniprot.org/core/author | "Zhong W."xsd:string |
| http://purl.uniprot.org/citations/12815436 | http://purl.uniprot.org/core/author | "Kipreos E.T."xsd:string |
| http://purl.uniprot.org/citations/12815436 | http://purl.uniprot.org/core/author | "Santiago F.E."xsd:string |
| http://purl.uniprot.org/citations/12815436 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12815436 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/12815436 | http://purl.uniprot.org/core/pages | "885-889"xsd:string |
| http://purl.uniprot.org/citations/12815436 | http://purl.uniprot.org/core/title | "CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing."xsd:string |
| http://purl.uniprot.org/citations/12815436 | http://purl.uniprot.org/core/volume | "423"xsd:string |
| http://purl.uniprot.org/citations/12815436 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12815436 |
| http://purl.uniprot.org/citations/12815436 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12815436 |
| http://purl.uniprot.org/uniprot/Q86S68#attribution-A36E72D9C84309F123CC175A896D81DD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12815436 |
| http://purl.uniprot.org/uniprot/#_Q17392-mappedCitation-12815436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12815436 |
| http://purl.uniprot.org/uniprot/#_Q86S68-mappedCitation-12815436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12815436 |
| http://purl.uniprot.org/uniprot/Q86S68 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12815436 |
| http://purl.uniprot.org/uniprot/Q17392 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12815436 |