| http://purl.uniprot.org/citations/12817010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12817010 | http://www.w3.org/2000/01/rdf-schema#comment | "CD8(+) T cells are required for protective immunity against intracellular pathogens such as Listeria monocytogenes. In this study, we used class Ia MHC-deficient mice, which have a severe reduction in circulating CD8(+) T cells, to determine the protective capacity of class Ib MHC-restricted T cells during L. monocytogenes infection. The K(b-/-)D(b-/-) mutation was backcrossed onto a C.B10 (BALB/c congenic at H-2 locus with C57BL/10) background, because BALB/c mice are more susceptible to Listeria infection than other commonly studied mouse strains such as C57BL/6. C.B10 K(b-/-)D(b-/-) mice immunized with a sublethal dose of L. monocytogenes were fully protected against a subsequent lethal infection. Adoptive transfer of Listeria-immune splenocyte subsets into naive K(b-/-)D(b-/-) mice indicated that CD8(+) T cells were the major component of this protective immune response. A CD8(+) T cell line isolated from the spleen of a Listeria-infected class Ia MHC-deficient mouse was shown to specifically recognize Listeria-infected cells in vitro, as determined by IFN-gamma secretion and cytotoxicity assays. Adoptive transfer of this T cell line alone resulted in significant protection against L. monocytogenes challenge. These results suggest that even a limited number of class Ib MHC-restricted T cells are sufficient to generate the rapid recall response required for protection against secondary infection with L. monocytogenes."xsd:string |
| http://purl.uniprot.org/citations/12817010 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.171.1.291"xsd:string |
| http://purl.uniprot.org/citations/12817010 | http://purl.uniprot.org/core/author | "Ploegh H.L."xsd:string |
| http://purl.uniprot.org/citations/12817010 | http://purl.uniprot.org/core/author | "Starnbach M.N."xsd:string |
| http://purl.uniprot.org/citations/12817010 | http://purl.uniprot.org/core/author | "D'Orazio S.E."xsd:string |
| http://purl.uniprot.org/citations/12817010 | http://purl.uniprot.org/core/author | "Halme D.G."xsd:string |
| http://purl.uniprot.org/citations/12817010 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12817010 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/12817010 | http://purl.uniprot.org/core/pages | "291-298"xsd:string |
| http://purl.uniprot.org/citations/12817010 | http://purl.uniprot.org/core/title | "Class Ia MHC-deficient BALB/c mice generate CD8+ T cell-mediated protective immunity against Listeria monocytogenes infection."xsd:string |
| http://purl.uniprot.org/citations/12817010 | http://purl.uniprot.org/core/volume | "171"xsd:string |
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