| http://purl.uniprot.org/citations/12819782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12819782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12819782 | http://www.w3.org/2000/01/rdf-schema#comment | "p38 is associated with a macromolecular tRNA synthetase complex. It has an essential role as a scaffold for the complex, and genetic disruption of p38 in mice causes neonatal lethality. Here we investigated the molecular mechanisms underlying lethality of p38-mutant mice. p38-deficient mice showed defects in lung differentiation and respiratory distress syndrome. p38 was found to interact with FUSE-binding protein (FBP), a transcriptional activator of c-myc. Binding of p38 stimulated ubiquitination and degradation of FBP, leading to downregulation of c-myc, which is required for differentiation of functional alveolar type II cells. Transforming growth factor-beta (TGF-beta) induced p38 expression and promoted its translocation to nuclei for the regulation of FBP and c-myc. Thus, this work identified a new activity of p38 as a mediator of TGF-beta signaling and its functional importance in the control of c-myc during lung differentiation."xsd:string |
| http://purl.uniprot.org/citations/12819782 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng1182"xsd:string |
| http://purl.uniprot.org/citations/12819782 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng1182"xsd:string |
| http://purl.uniprot.org/citations/12819782 | http://purl.uniprot.org/core/author | "Kim H.J."xsd:string |
| http://purl.uniprot.org/citations/12819782 | http://purl.uniprot.org/core/author | "Kim H.J."xsd:string |
| http://purl.uniprot.org/citations/12819782 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/12819782 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/12819782 | http://purl.uniprot.org/core/author | "Lee S.W."xsd:string |
| http://purl.uniprot.org/citations/12819782 | http://purl.uniprot.org/core/author | "Lee S.W."xsd:string |
| http://purl.uniprot.org/citations/12819782 | http://purl.uniprot.org/core/author | "Kim M.J."xsd:string |
| http://purl.uniprot.org/citations/12819782 | http://purl.uniprot.org/core/author | "Kim M.J."xsd:string |
| http://purl.uniprot.org/citations/12819782 | http://purl.uniprot.org/core/author | "Lee H.-W."xsd:string |
| http://purl.uniprot.org/citations/12819782 | http://purl.uniprot.org/core/author | "Lee H.-W."xsd:string |
| http://purl.uniprot.org/citations/12819782 | http://purl.uniprot.org/core/author | "Park J.-H."xsd:string |
| http://purl.uniprot.org/citations/12819782 | http://purl.uniprot.org/core/author | "Park J.-H."xsd:string |
| http://purl.uniprot.org/citations/12819782 | http://purl.uniprot.org/core/author | "Han J.M."xsd:string |
| http://purl.uniprot.org/citations/12819782 | http://purl.uniprot.org/core/author | "Han J.M."xsd:string |
| http://purl.uniprot.org/citations/12819782 | http://purl.uniprot.org/core/author | "Kang J.W."xsd:string |
| http://purl.uniprot.org/citations/12819782 | http://purl.uniprot.org/core/author | "Kang J.W."xsd:string |
| http://purl.uniprot.org/citations/12819782 | http://purl.uniprot.org/core/author | "Kang Y.-S."xsd:string |
| http://purl.uniprot.org/citations/12819782 | http://purl.uniprot.org/core/author | "Kang Y.-S."xsd:string |
| http://purl.uniprot.org/citations/12819782 | http://purl.uniprot.org/core/author | "Park B.-J."xsd:string |
| http://purl.uniprot.org/citations/12819782 | http://purl.uniprot.org/core/author | "Park B.-J."xsd:string |