| http://purl.uniprot.org/citations/12823467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12823467 | http://www.w3.org/2000/01/rdf-schema#comment | "Islet-Brain 1, also known as JNK-interacting protein-1 (IB1/JIP-1) is a scaffold protein mainly involved in the regulation of the pro-apoptotic signalling cascade mediated by c-Jun-N-terminal kinase (JNK). IB1/JIP-1 organizes JNK and upstream kinases in a complex that facilitates JNK activation. However, overexpression of IB1/JIP-1 in neurons in vitro has been reported to result in inhibition of JNK activation and protection against cellular stress and apoptosis. The occurrence and the functional significance of stress-induced modulations of IB1/JIP-1 levels in vivo are not known. We investigated the regulation of IB1/JIP-1 in mouse hippocampus after systemic administration of kainic acid (KA), in wild-type mice as well as in mice hemizygous for the gene MAPK8IP1, encoding for IB1/JIP-1. We show here that IB1/JIP-1 is upregulated transiently in the hippocampus of normal mice, reaching a peak 8 h after seizure induction. Heterozygous mutant mice underexpressing IB1/JIP-1 showed a higher vulnerability to the epileptogenic properties of KA, whereas hippocampal IB1/JIP-1 levels remained unchanged after seizure induction. Subsequently, an increasing activation of JNK in the 8 h following seizure induction was observed in IB1/JIP-1 haploinsufficient mice, which also underwent more severe excitotoxic lesions in hippocampal CA3, as assessed histologically 3 days after KA administration. Taken together, these data indicate that IB1/JIP-1 in hippocampus participates in the regulation of the neuronal response to excitotoxic stress in a level-dependent fashion."xsd:string |
| http://purl.uniprot.org/citations/12823467 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1460-9568.2003.02701.x"xsd:string |
| http://purl.uniprot.org/citations/12823467 | http://purl.uniprot.org/core/author | "Thompson N."xsd:string |
| http://purl.uniprot.org/citations/12823467 | http://purl.uniprot.org/core/author | "Waeber G."xsd:string |
| http://purl.uniprot.org/citations/12823467 | http://purl.uniprot.org/core/author | "Welker E."xsd:string |
| http://purl.uniprot.org/citations/12823467 | http://purl.uniprot.org/core/author | "Nicod P."xsd:string |
| http://purl.uniprot.org/citations/12823467 | http://purl.uniprot.org/core/author | "Riederer B."xsd:string |
| http://purl.uniprot.org/citations/12823467 | http://purl.uniprot.org/core/author | "Haefliger J.A."xsd:string |
| http://purl.uniprot.org/citations/12823467 | http://purl.uniprot.org/core/author | "Magara F."xsd:string |
| http://purl.uniprot.org/citations/12823467 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12823467 | http://purl.uniprot.org/core/name | "Eur J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/12823467 | http://purl.uniprot.org/core/pages | "2602-2610"xsd:string |
| http://purl.uniprot.org/citations/12823467 | http://purl.uniprot.org/core/title | "Increased vulnerability to kainic acid-induced epileptic seizures in mice underexpressing the scaffold protein Islet-Brain 1/JIP-1."xsd:string |
| http://purl.uniprot.org/citations/12823467 | http://purl.uniprot.org/core/volume | "17"xsd:string |
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