| http://purl.uniprot.org/citations/12824739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12824739 | http://www.w3.org/2000/01/rdf-schema#comment | "Several pieces of evidence showed that N-methyl D-aspartate (NMDA)-receptor-mediated decreases in function may be a causative factor for schizophrenia. The NMDA receptors are composed of a common glutamate receptor, an ionotropic NMDA 1 (GRIN1) subunit and one of four GRIN2 subunits (GRIN2A-GRIN2D), combined in an undetermined ratio to make up the receptor complex. In this study, we tested the hypothesis of whether the GRIN2B 366C/G and 2664C/T genetic polymorphisms are related to Chinese treatment-refractory schizophrenic patients. 193 treatment-refractory schizophrenic patients and 176 normal subjects were recruited for this study. The results demonstrated that the genotype distribution was similar between schizophrenic patients and control subjects in 366C/G (p = 0.88) and 2664C/T (p = 0.336), but we found a higher mean clozapine dosage in 2664C/C genotype patients. These results show that GRIN2B genetic variations were not a major risk factor for treatment-refractory schizophrenic patients, but may influence the effect of clozapine during treatment."xsd:string |
| http://purl.uniprot.org/citations/12824739 | http://purl.org/dc/terms/identifier | "doi:10.1159/000071211"xsd:string |
| http://purl.uniprot.org/citations/12824739 | http://purl.uniprot.org/core/author | "Chen J.Y."xsd:string |
| http://purl.uniprot.org/citations/12824739 | http://purl.uniprot.org/core/author | "Chiu H.J."xsd:string |
| http://purl.uniprot.org/citations/12824739 | http://purl.uniprot.org/core/author | "Wang Y.C."xsd:string |
| http://purl.uniprot.org/citations/12824739 | http://purl.uniprot.org/core/author | "Liou Y.J."xsd:string |
| http://purl.uniprot.org/citations/12824739 | http://purl.uniprot.org/core/author | "Lai I.C."xsd:string |
| http://purl.uniprot.org/citations/12824739 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12824739 | http://purl.uniprot.org/core/name | "Neuropsychobiology"xsd:string |
| http://purl.uniprot.org/citations/12824739 | http://purl.uniprot.org/core/pages | "178-181"xsd:string |
| http://purl.uniprot.org/citations/12824739 | http://purl.uniprot.org/core/title | "Association analysis of the genetic variants of the N-methyl D-aspartate receptor subunit 2b (NR2b) and treatment-refractory schizophrenia in the Chinese."xsd:string |
| http://purl.uniprot.org/citations/12824739 | http://purl.uniprot.org/core/volume | "47"xsd:string |
| http://purl.uniprot.org/citations/12824739 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12824739 |
| http://purl.uniprot.org/citations/12824739 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12824739 |
| http://purl.uniprot.org/uniprot/#_A0A8D9PHB2-mappedCitation-12824739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12824739 |
| http://purl.uniprot.org/uniprot/#_Q13224-mappedCitation-12824739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12824739 |
| http://purl.uniprot.org/uniprot/#_Q59HA9-mappedCitation-12824739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12824739 |
| http://purl.uniprot.org/uniprot/Q13224 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12824739 |
| http://purl.uniprot.org/uniprot/Q59HA9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12824739 |
| http://purl.uniprot.org/uniprot/A0A8D9PHB2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12824739 |