http://purl.uniprot.org/citations/12825172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/12825172 | http://www.w3.org/2000/01/rdf-schema#comment | "To investigate the influence of immunogenetics on response to interferon (IFN)-alpha treatment, human leukocyte antigen alleles were characterized in 100 unrelated Taiwanese patients with chronic hepatitis C virus (HCV) infection. A11, B51, Cw15, and DRB1*15 were positively correlated with sustained response, whereas A24 was inversely associated with response to IFN-alpha, after adjustment for cirrhosis, pretreatment virus load, and viral genotype. Homozygote-genotype analysis showed that A24 and DQB1*05 probably had gene-dosage effect on sustained response. DRB1*15 was in strong linkage disequilibrium with DQB1*05 and DQB1*06, but only haplotype DRB1*15-DQB1*05 was associated with response to IFN-alpha. Haplotype A11-DRB1*15 was strongly associated with sustained response. This suggests a role for a complex host-immunogenetics interplay in the response to IFN-alpha, in patients with chronic HCV infection."xsd:string |
http://purl.uniprot.org/citations/12825172 | http://purl.org/dc/terms/identifier | "doi:10.1086/375554"xsd:string |
http://purl.uniprot.org/citations/12825172 | http://purl.uniprot.org/core/author | "Chiu C.C."xsd:string |
http://purl.uniprot.org/citations/12825172 | http://purl.uniprot.org/core/author | "Wang L.Y."xsd:string |
http://purl.uniprot.org/citations/12825172 | http://purl.uniprot.org/core/author | "Chen S.C."xsd:string |
http://purl.uniprot.org/citations/12825172 | http://purl.uniprot.org/core/author | "Chang W.Y."xsd:string |
http://purl.uniprot.org/citations/12825172 | http://purl.uniprot.org/core/author | "Lin Z.Y."xsd:string |
http://purl.uniprot.org/citations/12825172 | http://purl.uniprot.org/core/author | "Chuang W.L."xsd:string |
http://purl.uniprot.org/citations/12825172 | http://purl.uniprot.org/core/author | "Hsieh M.Y."xsd:string |
http://purl.uniprot.org/citations/12825172 | http://purl.uniprot.org/core/author | "Dai C.Y."xsd:string |
http://purl.uniprot.org/citations/12825172 | http://purl.uniprot.org/core/author | "Yu M.L."xsd:string |
http://purl.uniprot.org/citations/12825172 | http://purl.uniprot.org/core/author | "Lee L.P."xsd:string |
http://purl.uniprot.org/citations/12825172 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
http://purl.uniprot.org/citations/12825172 | http://purl.uniprot.org/core/name | "J Infect Dis"xsd:string |
http://purl.uniprot.org/citations/12825172 | http://purl.uniprot.org/core/pages | "62-65"xsd:string |
http://purl.uniprot.org/citations/12825172 | http://purl.uniprot.org/core/title | "Human leukocyte antigen class I and II alleles and response to interferon-alpha treatment, in Taiwanese patients with chronic hepatitis C virus infection."xsd:string |
http://purl.uniprot.org/citations/12825172 | http://purl.uniprot.org/core/volume | "188"xsd:string |
http://purl.uniprot.org/citations/12825172 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12825172 |
http://purl.uniprot.org/citations/12825172 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12825172 |
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http://purl.uniprot.org/uniprot/#_A0A0A7C549-mappedCitation-12825172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12825172 |