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http://purl.uniprot.org/citations/12826154http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12826154http://www.w3.org/2000/01/rdf-schema#comment"

Unlabelled

High concentrations of retinol binding protein (RBP) are found in the urine of patients with tubulointerstitial injury. We evaluated the predictive value of urinary RBP (RBPu) for development graft dysfunction after kidney transplantation.

Methods

Serum creatinine and RBPu were prospectively measured at months 3, 6, and 12 in 221 kidney transplant patients. Baseline graft function was defined as the lowest serum creatinine value during the first 3 months after transplantation. Graft dysfunction was assessed at 1 year as a >-20% or >-30% change in the inverse creatinine ((Delta)1/Cr) compared to baseline value at month 3.

Results

Among 183 patients with normal graft function (Cr 0.6 mg/L (95% CI = -13% to -1.3%, P =.018). The percentage of patients with >-20% or >-30% (Delta)1/Cr was higher among patients with RBPu > 0.6 mg/L (34% vs 47%, P =.042; 21% vs 34%, P =.035). RBPu > 0.6 mg/L was the only variable independently associated with >-30% (Delta)1/Cr at 1 year, with an odds ratio (OR) of 1.95 (95% CI 0.99 to 3.80, P =.05).

Conclusions

RBPu may serve as a surrogate marker for graft dysfunction early after transplantation for patients with normal graft function, allowing early institution of intervention therapies to prolong allograft survival."xsd:string
http://purl.uniprot.org/citations/12826154http://purl.org/dc/terms/identifier"doi:10.1016/s0041-1345(03)00380-4"xsd:string
http://purl.uniprot.org/citations/12826154http://purl.uniprot.org/core/author"Park S.I."xsd:string
http://purl.uniprot.org/citations/12826154http://purl.uniprot.org/core/author"Pereira A.B."xsd:string
http://purl.uniprot.org/citations/12826154http://purl.uniprot.org/core/author"Medina-Pestana J.O."xsd:string
http://purl.uniprot.org/citations/12826154http://purl.uniprot.org/core/author"Garcia R.G."xsd:string
http://purl.uniprot.org/citations/12826154http://purl.uniprot.org/core/author"Felipe C.R."xsd:string
http://purl.uniprot.org/citations/12826154http://purl.uniprot.org/core/author"Hosaka B."xsd:string
http://purl.uniprot.org/citations/12826154http://purl.uniprot.org/core/author"Machado P.G."xsd:string
http://purl.uniprot.org/citations/12826154http://purl.uniprot.org/core/author"Tedesco-Silva H."xsd:string
http://purl.uniprot.org/citations/12826154http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12826154http://purl.uniprot.org/core/name"Transplant Proc"xsd:string
http://purl.uniprot.org/citations/12826154http://purl.uniprot.org/core/pages"1341-1343"xsd:string
http://purl.uniprot.org/citations/12826154http://purl.uniprot.org/core/title"Predictive value of urinary retinol binding protein for graft dysfunction after kidney transplantation."xsd:string
http://purl.uniprot.org/citations/12826154http://purl.uniprot.org/core/volume"35"xsd:string
http://purl.uniprot.org/citations/12826154http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12826154
http://purl.uniprot.org/citations/12826154http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12826154
http://purl.uniprot.org/uniprot/#_A0A0A0MQT0-mappedCitation-12826154http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12826154
http://purl.uniprot.org/uniprot/#_P09455-mappedCitation-12826154http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12826154
http://purl.uniprot.org/uniprot/A0A0A0MQT0http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/12826154
http://purl.uniprot.org/uniprot/P09455http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/12826154