| http://purl.uniprot.org/citations/12826378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12826378 | http://www.w3.org/2000/01/rdf-schema#comment | "To perform an investigation regarding the distribution of the human leukocyte antigen (HLA)-B27 subtypes in the Zulian population with ankylosing spondylitis (AS), 48 unrelated Mestizos, HLA-B27 positive by serology, were studied using the polymerase chain reaction-specific sequence oligonucleotides probe (PCR-SSOP) and specific sequence primers (SSP) to analyze the polymorphism in exons 2 and 3 of the HLA-B27 gene. Only two of eight HLA-B27 subtypes studied (B*2701-B*2708) were found. The distribution of these alleles in the population of patients was: B*2705, 68.8%, and B*2702, 31.2%. B*2705 subtype showed significant association with patients being male. In the healthy controls, the most common subtype was B*2708. These results were compared with frequencies reported in other Mestizo and Spanish populations and showed significant differences, such as a high frequency of B*2702. Such results show that HLA*B2705 and HLA*B2702 are the subtypes most frequently associated with AS in our Mestizo population and suggest a possible protector role for HLA*B2708, which was found only in the healthy population."xsd:string |
| http://purl.uniprot.org/citations/12826378 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0198-8859(03)00085-5"xsd:string |
| http://purl.uniprot.org/citations/12826378 | http://purl.uniprot.org/core/author | "Hernandez R."xsd:string |
| http://purl.uniprot.org/citations/12826378 | http://purl.uniprot.org/core/author | "Marquez G."xsd:string |
| http://purl.uniprot.org/citations/12826378 | http://purl.uniprot.org/core/author | "Rivera S."xsd:string |
| http://purl.uniprot.org/citations/12826378 | http://purl.uniprot.org/core/author | "Cipriani A."xsd:string |
| http://purl.uniprot.org/citations/12826378 | http://purl.uniprot.org/core/author | "Montiel M."xsd:string |
| http://purl.uniprot.org/citations/12826378 | http://purl.uniprot.org/core/author | "Villalobos C."xsd:string |
| http://purl.uniprot.org/citations/12826378 | http://purl.uniprot.org/core/author | "Hassanhi M."xsd:string |
| http://purl.uniprot.org/citations/12826378 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12826378 | http://purl.uniprot.org/core/name | "Hum Immunol"xsd:string |
| http://purl.uniprot.org/citations/12826378 | http://purl.uniprot.org/core/pages | "745-749"xsd:string |
| http://purl.uniprot.org/citations/12826378 | http://purl.uniprot.org/core/title | "HLA-B27 subtypes determination in patients with ankylosing spondylitis from Zulia, Venezuela."xsd:string |
| http://purl.uniprot.org/citations/12826378 | http://purl.uniprot.org/core/volume | "64"xsd:string |
| http://purl.uniprot.org/citations/12826378 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12826378 |
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