| http://purl.uniprot.org/citations/12829785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12829785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12829785 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-6 (IL-6) is an immunoregulatory cytokine that activates a cell-surface signaling assembly composed of IL-6, the IL-6 alpha-receptor (IL-6Ralpha), and the shared signaling receptor gp130. The 3.65 angstrom-resolution structure of the extracellular signaling complex reveals a hexameric, interlocking assembly mediated by a total of 10 symmetry-related, thermodynamically coupled interfaces. Assembly of the hexameric complex occurs sequentially: IL-6 is first engaged by IL-6Ralpha and then presented to gp130in the proper geometry to facilitate a cooperative transition into the high-affinity, signaling-competent hexamer. The quaternary structures of other IL-6/IL-12 family signaling complexes are likely constructed by means of a similar topological blueprint."xsd:string |
| http://purl.uniprot.org/citations/12829785 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1083901"xsd:string |
| http://purl.uniprot.org/citations/12829785 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1083901"xsd:string |
| http://purl.uniprot.org/citations/12829785 | http://purl.uniprot.org/core/author | "Boulanger M.J."xsd:string |
| http://purl.uniprot.org/citations/12829785 | http://purl.uniprot.org/core/author | "Boulanger M.J."xsd:string |
| http://purl.uniprot.org/citations/12829785 | http://purl.uniprot.org/core/author | "Garcia K.C."xsd:string |
| http://purl.uniprot.org/citations/12829785 | http://purl.uniprot.org/core/author | "Garcia K.C."xsd:string |
| http://purl.uniprot.org/citations/12829785 | http://purl.uniprot.org/core/author | "Chow D.C."xsd:string |
| http://purl.uniprot.org/citations/12829785 | http://purl.uniprot.org/core/author | "Chow D.C."xsd:string |
| http://purl.uniprot.org/citations/12829785 | http://purl.uniprot.org/core/author | "Brevnova E.E."xsd:string |
| http://purl.uniprot.org/citations/12829785 | http://purl.uniprot.org/core/author | "Brevnova E.E."xsd:string |
| http://purl.uniprot.org/citations/12829785 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12829785 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12829785 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12829785 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12829785 | http://purl.uniprot.org/core/pages | "2101-2104"xsd:string |
| http://purl.uniprot.org/citations/12829785 | http://purl.uniprot.org/core/pages | "2101-2104"xsd:string |
| http://purl.uniprot.org/citations/12829785 | http://purl.uniprot.org/core/title | "Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex."xsd:string |
| http://purl.uniprot.org/citations/12829785 | http://purl.uniprot.org/core/title | "Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex."xsd:string |
| http://purl.uniprot.org/citations/12829785 | http://purl.uniprot.org/core/volume | "300"xsd:string |
| http://purl.uniprot.org/citations/12829785 | http://purl.uniprot.org/core/volume | "300"xsd:string |
| http://purl.uniprot.org/citations/12829785 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12829785 |
| http://purl.uniprot.org/citations/12829785 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12829785 |