| http://purl.uniprot.org/citations/12829805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12829805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12829805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/12829805 | http://www.w3.org/2000/01/rdf-schema#comment | "The protein encoded by the HSD17B7 gene was originally described as a prolactin receptor-associated protein and as 17beta-hydroxysteroid dehydrogenase (HSD) type 7. Its ability to synthesize 17beta-estradiol in vitro has been reported previously. However, we demonstrate that HSD17B7 is the ortholog of the yeast 3-ketosteroid reductase Erg27p and converts zymosterone to zymosterol in vitro, using reduced nicotinamide adenine dinucleotide phosphate as cofactor. Expression of human and murine HSD17B7 in an Erg27p-deficient yeast strain complements the 3-ketosteroid reductase deficiency of the cells and restores growth on sterol-deficient medium. A fusion of HSD17B7 with green fluorescent protein is located in the endoplasmic reticulum, the site of postsqualene cholesterogenesis. Further critical evidence for a role of HSD17B7 in cholesterol metabolism is provided by the observation that its murine ortholog is a member of the same highly distinct embryonic synexpression group as hydroxymethyl-glutaryl-coenzyme A reductase, the rate-limiting enzyme of sterol biogenesis, and is specifically expressed in tissues that are involved in the pathogenesis of congenital cholesterol-deficiency disorders. We conclude that HSD17B7 participates in postsqualene cholesterol biosynthesis, thus completing the molecular cloning of all genes of this central metabolic pathway. In its function as the 3-ketosteroid reductase of cholesterol biosynthesis, HSD17B7 is a novel candidate for inborn errors of cholesterol metabolism."xsd:string |
| http://purl.uniprot.org/citations/12829805 | http://purl.org/dc/terms/identifier | "doi:10.1210/me.2002-0436"xsd:string |
| http://purl.uniprot.org/citations/12829805 | http://purl.org/dc/terms/identifier | "doi:10.1210/me.2002-0436"xsd:string |
| http://purl.uniprot.org/citations/12829805 | http://purl.uniprot.org/core/author | "Adamski J."xsd:string |
| http://purl.uniprot.org/citations/12829805 | http://purl.uniprot.org/core/author | "Adamski J."xsd:string |
| http://purl.uniprot.org/citations/12829805 | http://purl.uniprot.org/core/author | "Breitling R."xsd:string |
| http://purl.uniprot.org/citations/12829805 | http://purl.uniprot.org/core/author | "Breitling R."xsd:string |
| http://purl.uniprot.org/citations/12829805 | http://purl.uniprot.org/core/author | "Husen B."xsd:string |
| http://purl.uniprot.org/citations/12829805 | http://purl.uniprot.org/core/author | "Husen B."xsd:string |
| http://purl.uniprot.org/citations/12829805 | http://purl.uniprot.org/core/author | "Gege C."xsd:string |
| http://purl.uniprot.org/citations/12829805 | http://purl.uniprot.org/core/author | "Gege C."xsd:string |
| http://purl.uniprot.org/citations/12829805 | http://purl.uniprot.org/core/author | "Laubner D."xsd:string |
| http://purl.uniprot.org/citations/12829805 | http://purl.uniprot.org/core/author | "Laubner D."xsd:string |
| http://purl.uniprot.org/citations/12829805 | http://purl.uniprot.org/core/author | "Marijanovic Z."xsd:string |
| http://purl.uniprot.org/citations/12829805 | http://purl.uniprot.org/core/author | "Marijanovic Z."xsd:string |
| http://purl.uniprot.org/citations/12829805 | http://purl.uniprot.org/core/author | "Moeller G."xsd:string |
| http://purl.uniprot.org/citations/12829805 | http://purl.uniprot.org/core/author | "Moeller G."xsd:string |
| http://purl.uniprot.org/citations/12829805 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12829805 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12829805 | http://purl.uniprot.org/core/name | "Mol. Endocrinol."xsd:string |
| http://purl.uniprot.org/citations/12829805 | http://purl.uniprot.org/core/name | "Mol. Endocrinol."xsd:string |
| http://purl.uniprot.org/citations/12829805 | http://purl.uniprot.org/core/pages | "1715-1725"xsd:string |