| http://purl.uniprot.org/citations/12829839 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12829839 | http://www.w3.org/2000/01/rdf-schema#comment | "The genome of Bunyamwera virus (BUN; family Bunyaviridae, genus Orthobunyavirus) consists of three segments of negative-sense RNA. The smallest segment, S, encodes two proteins, the nonstructural protein NSs, which is nonessential for viral replication and transcription, and the nucleocapsid protein N. Although a precise role in the replication cycle has yet to be attributed to NSs, it has been shown that NSs inhibits the induction of alpha/beta interferon, suggesting that it plays a part in counteracting the host antiviral defense. A defense mechanism to limit viral spread is programmed cell death by apoptosis. Here we show that a recombinant BUN that does not express NSs (BUNdelNSs) induces apoptotic cell death more rapidly than wild-type virus. Screening for apoptosis pathways revealed that the proapoptotic transcription factor interferon regulatory factor 3 (IRF-3) was activated by both wild-type BUN and BUNdelNSs infection, but only wild-type BUN was able to suppress signaling downstream of IRF-3. Studies with a BUN minireplicon system showed that active replication induced an IRF-3-dependent promoter, which was suppressed by the NSs protein. In a cell line (P2.1) defective in double-stranded RNA signaling due to low levels of IRF-3, induction of apoptosis was similar for wild-type BUN and BUNdelNSs. These data suggest that the BUN NSs protein can delay cell death in the early stages of BUN infection by inhibiting IRF-3-mediated apoptosis."xsd:string |
| http://purl.uniprot.org/citations/12829839 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.77.14.7999-8008.2003"xsd:string |
| http://purl.uniprot.org/citations/12829839 | http://purl.uniprot.org/core/author | "Kohl A."xsd:string |
| http://purl.uniprot.org/citations/12829839 | http://purl.uniprot.org/core/author | "Elliott R.M."xsd:string |
| http://purl.uniprot.org/citations/12829839 | http://purl.uniprot.org/core/author | "Weber F."xsd:string |
| http://purl.uniprot.org/citations/12829839 | http://purl.uniprot.org/core/author | "Randall R.E."xsd:string |
| http://purl.uniprot.org/citations/12829839 | http://purl.uniprot.org/core/author | "Bridgen A."xsd:string |
| http://purl.uniprot.org/citations/12829839 | http://purl.uniprot.org/core/author | "Clayton R.F."xsd:string |
| http://purl.uniprot.org/citations/12829839 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12829839 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/12829839 | http://purl.uniprot.org/core/pages | "7999-8008"xsd:string |
| http://purl.uniprot.org/citations/12829839 | http://purl.uniprot.org/core/title | "Bunyamwera virus nonstructural protein NSs counteracts interferon regulatory factor 3-mediated induction of early cell death."xsd:string |
| http://purl.uniprot.org/citations/12829839 | http://purl.uniprot.org/core/volume | "77"xsd:string |
| http://purl.uniprot.org/citations/12829839 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12829839 |
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