| http://purl.uniprot.org/citations/12830000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12830000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12830000 | http://www.w3.org/2000/01/rdf-schema#comment | "Wnt signaling mediated by beta-catenin plays crucial roles in the development of hepatocellular carcinoma and other cancers such as colorectal cancer. beta-Catenin associates with T-cell factor (TCF) transcription factors and functions as a transcriptional activator in the nucleus. By protein interaction screening, we identified EBP50, a cytoplasmic protein with 2 PDZ domains, as a beta-catenin-associating molecule. EBP50 interacted with beta-catenin through its carboxyl-PDZ domain in vitro and in vivo. Northern blot and RT-PCR analysis revealed an increase of EBP50 messenger RNA (mRNA) in hepatocellular carcinoma (HCC) cell lines and surgical specimens of human HCC. Over-expression of EBP50 protein with focal nuclear localization was detected in human HCC. In human HCC and colorectal cancer cell lines, EBP50 enhanced beta-catenin/TCF-dependent transcription in a dose-dependent manner. In an HCC cell line, over-expression of the carboxyl PDZ domain resulted in a decrease of endogenous beta-catenin/TCF transactivation. EBP50 promoted beta-catenin-mediated transactivation only in cells in which beta-catenin was already stabilized, suggesting that EBP50 may work with stabilized beta-catenin for transcriptional regulation. In conclusion, the EBP50/beta-catenin complex promotes Wnt signaling, and over-expression of EBP50 may work cooperatively with beta-catenin in the development of liver cancer."xsd:string |
| http://purl.uniprot.org/citations/12830000 | http://purl.org/dc/terms/identifier | "doi:10.1053/jhep.2003.50270"xsd:string |
| http://purl.uniprot.org/citations/12830000 | http://purl.org/dc/terms/identifier | "doi:10.1053/jhep.2003.50270"xsd:string |
| http://purl.uniprot.org/citations/12830000 | http://purl.uniprot.org/core/author | "Shibata T."xsd:string |
| http://purl.uniprot.org/citations/12830000 | http://purl.uniprot.org/core/author | "Shibata T."xsd:string |
| http://purl.uniprot.org/citations/12830000 | http://purl.uniprot.org/core/author | "Sakamoto M."xsd:string |
| http://purl.uniprot.org/citations/12830000 | http://purl.uniprot.org/core/author | "Sakamoto M."xsd:string |
| http://purl.uniprot.org/citations/12830000 | http://purl.uniprot.org/core/author | "Hirohashi S."xsd:string |
| http://purl.uniprot.org/citations/12830000 | http://purl.uniprot.org/core/author | "Hirohashi S."xsd:string |
| http://purl.uniprot.org/citations/12830000 | http://purl.uniprot.org/core/author | "Kokubu A."xsd:string |
| http://purl.uniprot.org/citations/12830000 | http://purl.uniprot.org/core/author | "Kokubu A."xsd:string |
| http://purl.uniprot.org/citations/12830000 | http://purl.uniprot.org/core/author | "Chuma M."xsd:string |
| http://purl.uniprot.org/citations/12830000 | http://purl.uniprot.org/core/author | "Chuma M."xsd:string |
| http://purl.uniprot.org/citations/12830000 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12830000 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12830000 | http://purl.uniprot.org/core/name | "Hepatology"xsd:string |
| http://purl.uniprot.org/citations/12830000 | http://purl.uniprot.org/core/name | "Hepatology"xsd:string |
| http://purl.uniprot.org/citations/12830000 | http://purl.uniprot.org/core/pages | "178-186"xsd:string |
| http://purl.uniprot.org/citations/12830000 | http://purl.uniprot.org/core/pages | "178-186"xsd:string |
| http://purl.uniprot.org/citations/12830000 | http://purl.uniprot.org/core/title | "EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma."xsd:string |
| http://purl.uniprot.org/citations/12830000 | http://purl.uniprot.org/core/title | "EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma."xsd:string |
| http://purl.uniprot.org/citations/12830000 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/12830000 | http://purl.uniprot.org/core/volume | "38"xsd:string |