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http://purl.uniprot.org/citations/12832367http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12832367http://www.w3.org/2000/01/rdf-schema#comment"

Background

Regulation of the LH surge is central to the functioning of the female ovulatory cycle. In animal models, oxytocin has been shown to alter LH activity. Oxytocin advanced the LH surge and, conversely, oxytocin receptor antagonists inhibited full production of the LH surge in rats. Few data exist on the possibility that oxytocin modulates LH in women.

Methods

Ten non-pregnant women participated in this study over two menstrual cycles. One cycle was a control cycle, and the other a trial cycle; the two were separated by at least one cycle. When the diameter of an ovarian follicle was >15 mm, a subject was allocated at random into either a control or treatment group. In a control cycle, volunteers received normal saline; in a treatment cycle, volunteers received an oxytocin antagonist (atosiban).

Results

For treatment cycles, the maximum LH concentration was significantly less than that in control cycles (42.1 +/- 6.2 versus 60.3 +/-8.3 IU/l respectively; P < 0.05). Maximum FSH and estradiol concentrations were not significantly different between the two groups.

Conclusions

The results indicated that inhibition of endogenous oxytocin affects the endocrinology of the ovulatory cycle in women, and strongly suggest that oxytocin has a role in the physiological processes of LH regulation."xsd:string
http://purl.uniprot.org/citations/12832367http://purl.org/dc/terms/identifier"doi:10.1093/humrep/deg291"xsd:string
http://purl.uniprot.org/citations/12832367http://purl.uniprot.org/core/author"Reid R.A."xsd:string
http://purl.uniprot.org/citations/12832367http://purl.uniprot.org/core/author"Evans J.J."xsd:string
http://purl.uniprot.org/citations/12832367http://purl.uniprot.org/core/author"Benny P.S."xsd:string
http://purl.uniprot.org/citations/12832367http://purl.uniprot.org/core/author"Croft L.B."xsd:string
http://purl.uniprot.org/citations/12832367http://purl.uniprot.org/core/author"Wakeman S.A."xsd:string
http://purl.uniprot.org/citations/12832367http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12832367http://purl.uniprot.org/core/name"Hum Reprod"xsd:string
http://purl.uniprot.org/citations/12832367http://purl.uniprot.org/core/pages"1428-1431"xsd:string
http://purl.uniprot.org/citations/12832367http://purl.uniprot.org/core/title"Evidence that oxytocin is a physiological component of LH regulation in non-pregnant women."xsd:string
http://purl.uniprot.org/citations/12832367http://purl.uniprot.org/core/volume"18"xsd:string
http://purl.uniprot.org/citations/12832367http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12832367
http://purl.uniprot.org/citations/12832367http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12832367
http://purl.uniprot.org/uniprot/#_P01178-mappedCitation-12832367http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12832367
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