| http://purl.uniprot.org/citations/12835418 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12835418 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12835418 | http://www.w3.org/2000/01/rdf-schema#comment | "We have developed a semiempirical algorithm called Family Values (FamVal), which identifies residues that encode functional specificity in a protein sequence. Given a multiple sequence alignment (MSA) grouped into functionally distinct subfamilies, FamVal calculates a specificity score for each subfamily at every amino acid position of an MSA. This algorithm was used to predict specificity-encoding positions within the tetramerization assembly (T1) domain of voltage-gated potassium (Kv) channel subfamilies Kv3 and Kv4. The importance of one such position (Arg to Ala at MSA position 93) was confirmed by in vitro pull-down assays. The structural basis of this assembly discrimination was elucidated by determining the crystal structure of the Kv4 T1 domain and comparing it to the Kv3 T1 domain."xsd:string |
| http://purl.uniprot.org/citations/12835418 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1432840100"xsd:string |
| http://purl.uniprot.org/citations/12835418 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1432840100"xsd:string |
| http://purl.uniprot.org/citations/12835418 | http://purl.uniprot.org/core/author | "Zhou W."xsd:string |
| http://purl.uniprot.org/citations/12835418 | http://purl.uniprot.org/core/author | "Zhou W."xsd:string |
| http://purl.uniprot.org/citations/12835418 | http://purl.uniprot.org/core/author | "Choe S."xsd:string |
| http://purl.uniprot.org/citations/12835418 | http://purl.uniprot.org/core/author | "Choe S."xsd:string |
| http://purl.uniprot.org/citations/12835418 | http://purl.uniprot.org/core/author | "Nanao M.H."xsd:string |
| http://purl.uniprot.org/citations/12835418 | http://purl.uniprot.org/core/author | "Nanao M.H."xsd:string |
| http://purl.uniprot.org/citations/12835418 | http://purl.uniprot.org/core/author | "Pfaffinger P.J."xsd:string |
| http://purl.uniprot.org/citations/12835418 | http://purl.uniprot.org/core/author | "Pfaffinger P.J."xsd:string |
| http://purl.uniprot.org/citations/12835418 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12835418 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12835418 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/12835418 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/12835418 | http://purl.uniprot.org/core/pages | "8670-8675"xsd:string |
| http://purl.uniprot.org/citations/12835418 | http://purl.uniprot.org/core/pages | "8670-8675"xsd:string |
| http://purl.uniprot.org/citations/12835418 | http://purl.uniprot.org/core/title | "Determining the basis of channel-tetramerization specificity by X-ray crystallography and a sequence-comparison algorithm: family values (FamVal)."xsd:string |
| http://purl.uniprot.org/citations/12835418 | http://purl.uniprot.org/core/title | "Determining the basis of channel-tetramerization specificity by X-ray crystallography and a sequence-comparison algorithm: family values (FamVal)."xsd:string |
| http://purl.uniprot.org/citations/12835418 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/12835418 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/12835418 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12835418 |
| http://purl.uniprot.org/citations/12835418 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12835418 |