| http://purl.uniprot.org/citations/12835475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12835475 | http://www.w3.org/2000/01/rdf-schema#comment | "Differentiation of naive CD4+ T cells into helper T (Th) cells is controlled by a combination of several transcriptional factors. In this study, we examined the functional role of the Runx1 transcription factor in Th cell differentiation. Naive T cells from transgenic mice expressing a dominant interfering form of Runx1 exhibited enhanced interleukin 4 production and efficient Th2 differentiation. In contrast, transduction of Runx1 into wild-type T cells caused a complete attenuation of Th2 differentiation and was accompanied by the cessation of GATA3 expression. Furthermore, endogenous expression of Runx1 in naive T cells declined after T cell receptor stimulation, at the same time that expression of GATA3 increased. We conclude that Runx1 plays a novel role as a negative regulator of GATA3 expression, thereby inhibiting the Th2 cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/12835475 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20021200"xsd:string |
| http://purl.uniprot.org/citations/12835475 | http://purl.uniprot.org/core/author | "Hayashi K."xsd:string |
| http://purl.uniprot.org/citations/12835475 | http://purl.uniprot.org/core/author | "Kubo M."xsd:string |
| http://purl.uniprot.org/citations/12835475 | http://purl.uniprot.org/core/author | "Watanabe T."xsd:string |
| http://purl.uniprot.org/citations/12835475 | http://purl.uniprot.org/core/author | "Seki Y."xsd:string |
| http://purl.uniprot.org/citations/12835475 | http://purl.uniprot.org/core/author | "Seki N."xsd:string |
| http://purl.uniprot.org/citations/12835475 | http://purl.uniprot.org/core/author | "Satake M."xsd:string |
| http://purl.uniprot.org/citations/12835475 | http://purl.uniprot.org/core/author | "Habu S."xsd:string |
| http://purl.uniprot.org/citations/12835475 | http://purl.uniprot.org/core/author | "Yagi R."xsd:string |
| http://purl.uniprot.org/citations/12835475 | http://purl.uniprot.org/core/author | "Hozumi K."xsd:string |
| http://purl.uniprot.org/citations/12835475 | http://purl.uniprot.org/core/author | "Komine O."xsd:string |
| http://purl.uniprot.org/citations/12835475 | http://purl.uniprot.org/core/author | "Natsume W."xsd:string |
| http://purl.uniprot.org/citations/12835475 | http://purl.uniprot.org/core/author | "Tamauchi H."xsd:string |
| http://purl.uniprot.org/citations/12835475 | http://purl.uniprot.org/core/author | "Sukzuki W."xsd:string |
| http://purl.uniprot.org/citations/12835475 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12835475 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/12835475 | http://purl.uniprot.org/core/pages | "51-61"xsd:string |
| http://purl.uniprot.org/citations/12835475 | http://purl.uniprot.org/core/title | "The Runx1 transcription factor inhibits the differentiation of naive CD4+ T cells into the Th2 lineage by repressing GATA3 expression."xsd:string |
| http://purl.uniprot.org/citations/12835475 | http://purl.uniprot.org/core/volume | "198"xsd:string |
| http://purl.uniprot.org/citations/12835475 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12835475 |
| http://purl.uniprot.org/citations/12835475 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12835475 |
| http://purl.uniprot.org/uniprot/#_A0A087WPL0-mappedCitation-12835475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12835475 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RNW1-mappedCitation-12835475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12835475 |