| http://purl.uniprot.org/citations/12835617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12835617 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of the study was to investigate whether genetic variation in the peroxisome proliferator-activated receptor-alpha (PPARalpha) is associated with type 2 diabetes and altered lipid or carbohydrate metabolism in glucose tolerant subjects. Mutation analyses of PPARalpha were performed in 56 type 2 diabetic patients. Six variants were identified: IVS3 + 76T>C, IVS3-19C>T, IVS4 + 35C>T, Leu162Val, Arg178Gly and Ala268Val. In a case-control study comprising 738 type 2 diabetic patients and 524 glucose tolerant subjects, the three exon variants did not show any significant differences in allele frequencies between type 2 diabetic patients and control subjects. The functional Leu162Val polymorphism was further investigated in genotype-phenotype studies involving 340 young, healthy subjects and 502 middle-aged glucose tolerant subjects. The young, healthy subjects who were heterozygous for the Leu162Val variant had, on average, a 20% decrease in fasting serum triglyceride levels (P=0.014). This finding was replicated in middle-aged subjects (P=0.023). The Leu162Val polymorphism was not related to alterations in insulin sensitivity, insulin release or level of glycaemia. In conclusion, the Leu162Val polymorphism of PPARalpha is associated with a decreased level of fasting serum triglyceride in glucose tolerant white subjects."xsd:string |
| http://purl.uniprot.org/citations/12835617 | http://purl.org/dc/terms/identifier | "doi:10.1097/01.fpc.0000054105.48725.5c"xsd:string |
| http://purl.uniprot.org/citations/12835617 | http://purl.uniprot.org/core/author | "Ekstrom C.T."xsd:string |
| http://purl.uniprot.org/citations/12835617 | http://purl.uniprot.org/core/author | "Hansen T."xsd:string |
| http://purl.uniprot.org/citations/12835617 | http://purl.uniprot.org/core/author | "Hansen L."xsd:string |
| http://purl.uniprot.org/citations/12835617 | http://purl.uniprot.org/core/author | "Echwald S.M."xsd:string |
| http://purl.uniprot.org/citations/12835617 | http://purl.uniprot.org/core/author | "Pedersen O."xsd:string |
| http://purl.uniprot.org/citations/12835617 | http://purl.uniprot.org/core/author | "Nielsen E.M."xsd:string |
| http://purl.uniprot.org/citations/12835617 | http://purl.uniprot.org/core/author | "Borch-Johnsen K."xsd:string |
| http://purl.uniprot.org/citations/12835617 | http://purl.uniprot.org/core/author | "Drivsholm T."xsd:string |
| http://purl.uniprot.org/citations/12835617 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12835617 | http://purl.uniprot.org/core/name | "Pharmacogenetics"xsd:string |
| http://purl.uniprot.org/citations/12835617 | http://purl.uniprot.org/core/pages | "417-423"xsd:string |
| http://purl.uniprot.org/citations/12835617 | http://purl.uniprot.org/core/title | "Evidence for an association between the Leu162Val polymorphism of the PPARalpha gene and decreased fasting serum triglyceride levels in glucose tolerant subjects."xsd:string |
| http://purl.uniprot.org/citations/12835617 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/12835617 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12835617 |
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