| http://purl.uniprot.org/citations/12837291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12837291 | http://www.w3.org/2000/01/rdf-schema#comment | "The nucleoprotein structure of the mouse mammary tumor virus (MMTV) promoter defines its response to cAMP signaling. A stably replicating MMTV template in highly organized chromatin is repressed in the presence of cAMP, whereas a transiently transfected template with a disorganized structure is activated. In this study, we investigate the nature of the cAMP-induced signal(s) by which these opposing responses occur to gain insight into their mechanism. We demonstrate that the transcriptional changes observed at both templates are mediated through cAMP-dependent protein kinase A (PKA). In addition, the MMTV promoter lacks a consensus cAMP response element (CRE) and neither template requires cAMP response element-binding protein (CREB) to elicit a response to cAMP signaling. However, the responses of the two templates differ mechanistically in that the CREB-binding protein p300 potentiates activation from the transient template in a manner dependent on its Cys/His-rich region 3, but does not appear to affect the repression of the replicating chromatin template. Chromatin immunoprecipitation assays show that cAMP treatment results in a decrease in acetylation of histone H4, and in multiple modifications of histone H3 at specific nucleosomes in the promoter region of the stable MMTV template. These findings suggest novel CREB-independent, chromatin-dependent pathways for transcriptional regulation by cAMP."xsd:string |
| http://purl.uniprot.org/citations/12837291 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-4827(03)00153-8"xsd:string |
| http://purl.uniprot.org/citations/12837291 | http://purl.uniprot.org/core/author | "Smith C.L."xsd:string |
| http://purl.uniprot.org/citations/12837291 | http://purl.uniprot.org/core/author | "Kolla S.S."xsd:string |
| http://purl.uniprot.org/citations/12837291 | http://purl.uniprot.org/core/author | "Mulholland N.M."xsd:string |
| http://purl.uniprot.org/citations/12837291 | http://purl.uniprot.org/core/author | "Snyder S.K."xsd:string |
| http://purl.uniprot.org/citations/12837291 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12837291 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/12837291 | http://purl.uniprot.org/core/pages | "361-373"xsd:string |
| http://purl.uniprot.org/citations/12837291 | http://purl.uniprot.org/core/title | "Chromatin-dependent regulation of the MMTV promoter by cAMP signaling is mediated through distinct pathways."xsd:string |
| http://purl.uniprot.org/citations/12837291 | http://purl.uniprot.org/core/volume | "287"xsd:string |
| http://purl.uniprot.org/citations/12837291 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12837291 |
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