| http://purl.uniprot.org/citations/12840007 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12840007 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12840007 | http://www.w3.org/2000/01/rdf-schema#comment | "Oligonucleosomal fragmentation of chromosomes in dying cells is a hallmark of apoptosis. Little is known about how it is executed or what cellular components are involved. We show that crn-1, a Caenorhabditis elegans homologue of human flap endonuclease-1 (FEN-1) that is normally involved in DNA replication and repair, is also important for apoptosis. Reduction of crn-1 activity by RNA interference resulted in cell death phenotypes similar to those displayed by a mutant lacking the mitochondrial endonuclease CPS-6/endonuclease G. CRN-1 localizes to nuclei and can associate and cooperate with CPS-6 to promote stepwise DNA fragmentation, utilizing the endonuclease activity of CPS-6 and both the 5'-3' exonuclease activity and a previously uncharacterized gap-dependent endonuclease activity of CRN-1. Our results suggest that CRN-1/FEN-1 may play a critical role in switching the state of cells from DNA replication/repair to DNA degradation during apoptosis."xsd:string |
| http://purl.uniprot.org/citations/12840007 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg320"xsd:string |
| http://purl.uniprot.org/citations/12840007 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg320"xsd:string |
| http://purl.uniprot.org/citations/12840007 | http://purl.uniprot.org/core/author | "Shen B."xsd:string |
| http://purl.uniprot.org/citations/12840007 | http://purl.uniprot.org/core/author | "Shen B."xsd:string |
| http://purl.uniprot.org/citations/12840007 | http://purl.uniprot.org/core/author | "Yang C."xsd:string |
| http://purl.uniprot.org/citations/12840007 | http://purl.uniprot.org/core/author | "Yang C."xsd:string |
| http://purl.uniprot.org/citations/12840007 | http://purl.uniprot.org/core/author | "Xue D."xsd:string |
| http://purl.uniprot.org/citations/12840007 | http://purl.uniprot.org/core/author | "Xue D."xsd:string |
| http://purl.uniprot.org/citations/12840007 | http://purl.uniprot.org/core/author | "Parrish J.Z."xsd:string |
| http://purl.uniprot.org/citations/12840007 | http://purl.uniprot.org/core/author | "Parrish J.Z."xsd:string |
| http://purl.uniprot.org/citations/12840007 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12840007 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12840007 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/12840007 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/12840007 | http://purl.uniprot.org/core/pages | "3451-3460"xsd:string |
| http://purl.uniprot.org/citations/12840007 | http://purl.uniprot.org/core/pages | "3451-3460"xsd:string |
| http://purl.uniprot.org/citations/12840007 | http://purl.uniprot.org/core/title | "CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation."xsd:string |
| http://purl.uniprot.org/citations/12840007 | http://purl.uniprot.org/core/title | "CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation."xsd:string |
| http://purl.uniprot.org/citations/12840007 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12840007 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12840007 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12840007 |
| http://purl.uniprot.org/citations/12840007 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12840007 |