| http://purl.uniprot.org/citations/12842048 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12842048 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12842048 | http://www.w3.org/2000/01/rdf-schema#comment | "The enzymatic digestion of cellulose entails intimate involvement of cellobiohydrolases, whose characteristic active-center tunnel contributes to a processive degradation of the polysaccharide. The cellobiohydrolase Cel6A displays an active site within a tunnel formed by two extended loops, which are known to open and close in response to ligand binding. Here we present five structures of wild-type and mutant forms of Cel6A from Humicola insolens in complex with nonhydrolyzable thio-oligosaccharides, at resolutions from 1.7-1.1 A, dissecting the structural accommodation of a processing substrate chain through the active center during hydrolysis. Movement of ligand is facilitated by extensive solvent-mediated interactions and through flexibility in the hydrophobic surfaces provided by a sheath of tryptophan residues."xsd:string |
| http://purl.uniprot.org/citations/12842048 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0969-2126(03)00124-2"xsd:string |
| http://purl.uniprot.org/citations/12842048 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0969-2126(03)00124-2"xsd:string |
| http://purl.uniprot.org/citations/12842048 | http://purl.uniprot.org/core/author | "Davies G.J."xsd:string |
| http://purl.uniprot.org/citations/12842048 | http://purl.uniprot.org/core/author | "Davies G.J."xsd:string |
| http://purl.uniprot.org/citations/12842048 | http://purl.uniprot.org/core/author | "Varrot A."xsd:string |
| http://purl.uniprot.org/citations/12842048 | http://purl.uniprot.org/core/author | "Varrot A."xsd:string |
| http://purl.uniprot.org/citations/12842048 | http://purl.uniprot.org/core/author | "Driguez H."xsd:string |
| http://purl.uniprot.org/citations/12842048 | http://purl.uniprot.org/core/author | "Driguez H."xsd:string |
| http://purl.uniprot.org/citations/12842048 | http://purl.uniprot.org/core/author | "Frandsen T.P."xsd:string |
| http://purl.uniprot.org/citations/12842048 | http://purl.uniprot.org/core/author | "Frandsen T.P."xsd:string |
| http://purl.uniprot.org/citations/12842048 | http://purl.uniprot.org/core/author | "von Ossowski I."xsd:string |
| http://purl.uniprot.org/citations/12842048 | http://purl.uniprot.org/core/author | "von Ossowski I."xsd:string |
| http://purl.uniprot.org/citations/12842048 | http://purl.uniprot.org/core/author | "Cottaz S."xsd:string |
| http://purl.uniprot.org/citations/12842048 | http://purl.uniprot.org/core/author | "Cottaz S."xsd:string |
| http://purl.uniprot.org/citations/12842048 | http://purl.uniprot.org/core/author | "Boyer V."xsd:string |
| http://purl.uniprot.org/citations/12842048 | http://purl.uniprot.org/core/author | "Boyer V."xsd:string |
| http://purl.uniprot.org/citations/12842048 | http://purl.uniprot.org/core/author | "Schuelein M."xsd:string |
| http://purl.uniprot.org/citations/12842048 | http://purl.uniprot.org/core/author | "Schuelein M."xsd:string |
| http://purl.uniprot.org/citations/12842048 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12842048 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12842048 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/12842048 | http://purl.uniprot.org/core/name | "Structure"xsd:string |