| http://purl.uniprot.org/citations/12845430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12845430 | http://www.w3.org/2000/01/rdf-schema#comment | "Aims/hypothesisEnterovirus infections are among the environmental risk factors potentially contributing to the pathogenesis of Type 1 diabetes. The aim of this study was to evaluate virus-host interaction by analysing the enterovirus antibody levels in subjects carrying different HLA-DR alleles associated with either increased or decreased risk of Type 1 diabetes.MethodsAntibodies against coxsackievirus B4 were measured to study immune responses induced by natural enterovirus infections and against poliovirus 1 to study immune responses induced by immunisation by enterovirus antigens (vaccine). Antibodies against the mumps virus were measured as a control. Study subjects included siblings of children with Type 1 diabetes taking part in the Childhood Diabetes in Finland (DiMe) Study and carrying either HLA-DR risk (DR3 and/or DR4) or protective (DR2) alleles.ResultsChildren with either the HLA-DR3 or HLA-DR4 allele and those with both these risk alleles had higher Coxsackie B4 antibody levels than children carrying the HLA-DR2 allele ( p=0.01, p=0.01 and p=0.008, respectively). High responders (IgG levels higher than 75 percent) were also more frequent among genetically susceptible children compared to children with the protective DR2 allele (27% vs 12%) ( p<0.009). The same trend was seen for poliovirus antibodies, while mumps antibody levels had a different pattern (high responders more common among DR2-positive subjects).Conclusions/interpretationDiabetes-associated HLA-DR risk alleles were associated with a strong immune responsiveness and protective alleles with a weak responsiveness against enterovirus antigens. This phenomenon should be taken into consideration in serological case-control studies and it might play a role in virus-induced beta-cell damage."xsd:string |
| http://purl.uniprot.org/citations/12845430 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00125-003-1157-x"xsd:string |
| http://purl.uniprot.org/citations/12845430 | http://purl.uniprot.org/core/author | "Hiltunen M."xsd:string |
| http://purl.uniprot.org/citations/12845430 | http://purl.uniprot.org/core/author | "Knip M."xsd:string |
| http://purl.uniprot.org/citations/12845430 | http://purl.uniprot.org/core/author | "Hyoty H."xsd:string |
| http://purl.uniprot.org/citations/12845430 | http://purl.uniprot.org/core/author | "Akerblom H.K."xsd:string |
| http://purl.uniprot.org/citations/12845430 | http://purl.uniprot.org/core/author | "Sadeharju K."xsd:string |
| http://purl.uniprot.org/citations/12845430 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12845430 | http://purl.uniprot.org/core/name | "Diabetologia"xsd:string |
| http://purl.uniprot.org/citations/12845430 | http://purl.uniprot.org/core/pages | "1100-1105"xsd:string |
| http://purl.uniprot.org/citations/12845430 | http://purl.uniprot.org/core/title | "The HLA-DR phenotype modulates the humoral immune response to enterovirus antigens."xsd:string |
| http://purl.uniprot.org/citations/12845430 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/12845430 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12845430 |
| http://purl.uniprot.org/citations/12845430 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12845430 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-12845430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12845430 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-12845430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12845430 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-12845430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12845430 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-12845430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12845430 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD66-mappedCitation-12845430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12845430 |
| http://purl.uniprot.org/uniprot/#_A0A141AZI1-mappedCitation-12845430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12845430 |
| http://purl.uniprot.org/uniprot/#_A0A141AZI3-mappedCitation-12845430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12845430 |
| http://purl.uniprot.org/uniprot/#_A0A141AZI4-mappedCitation-12845430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12845430 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WAE5-mappedCitation-12845430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12845430 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WB88-mappedCitation-12845430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12845430 |