| http://purl.uniprot.org/citations/12847090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12847090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12847090 | http://www.w3.org/2000/01/rdf-schema#comment | "Che-1 is a recently identified human RNA polymerase II binding protein involved in the regulation of gene transcription and cell proliferation. We previously demonstrated that Che-1 inhibits the Rb growth-suppressing function by interfering with Rb-mediated HDAC1 recruitment on E2F target gene promoters. By hybridization of cancer profile arrays, we found that Che-1 expression is strongly down-regulated in several tumors, including colon and kidney carcinomas, compared with the relative normal tissues. Consistent with these data, Che-1 overexpression inhibits proliferation of HCT116 and LoVo human colon carcinoma cell lines by activation of the cyclin-dependent kinase inhibitor p21WAF1/Cip1 in a p53-independent manner and by promoting growth arrest at the G1 phase of the cell cycle. Che-1 activates p21WAF1/Cip1 by displacing histone deacetylase (HDAC)1 from the Sp1 binding sites of the p21WAF1/Cip1 gene promoter and accumulating acetylated histone H3 on these sites. Accordingly, Che-1-specific RNA interference negatively affects p21WAF1/Cip1 transactivation and increases cell proliferation in HCT116 cells. Taken together, our results indicate that Che-1 can be considered a general HDAC1 competitor and its down-regulation is involved in colon carcinoma cell proliferation."xsd:string |
| http://purl.uniprot.org/citations/12847090 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m306694200"xsd:string |
| http://purl.uniprot.org/citations/12847090 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m306694200"xsd:string |
| http://purl.uniprot.org/citations/12847090 | http://purl.uniprot.org/core/author | "Biroccio A."xsd:string |
| http://purl.uniprot.org/citations/12847090 | http://purl.uniprot.org/core/author | "Biroccio A."xsd:string |
| http://purl.uniprot.org/citations/12847090 | http://purl.uniprot.org/core/author | "Bruno T."xsd:string |
| http://purl.uniprot.org/citations/12847090 | http://purl.uniprot.org/core/author | "Bruno T."xsd:string |
| http://purl.uniprot.org/citations/12847090 | http://purl.uniprot.org/core/author | "Corbi N."xsd:string |
| http://purl.uniprot.org/citations/12847090 | http://purl.uniprot.org/core/author | "Corbi N."xsd:string |
| http://purl.uniprot.org/citations/12847090 | http://purl.uniprot.org/core/author | "D'Angelo C."xsd:string |
| http://purl.uniprot.org/citations/12847090 | http://purl.uniprot.org/core/author | "D'Angelo C."xsd:string |
| http://purl.uniprot.org/citations/12847090 | http://purl.uniprot.org/core/author | "De Nicola F."xsd:string |
| http://purl.uniprot.org/citations/12847090 | http://purl.uniprot.org/core/author | "De Nicola F."xsd:string |
| http://purl.uniprot.org/citations/12847090 | http://purl.uniprot.org/core/author | "Di Padova M."xsd:string |
| http://purl.uniprot.org/citations/12847090 | http://purl.uniprot.org/core/author | "Di Padova M."xsd:string |
| http://purl.uniprot.org/citations/12847090 | http://purl.uniprot.org/core/author | "Fanciulli M."xsd:string |
| http://purl.uniprot.org/citations/12847090 | http://purl.uniprot.org/core/author | "Fanciulli M."xsd:string |
| http://purl.uniprot.org/citations/12847090 | http://purl.uniprot.org/core/author | "Floridi A."xsd:string |
| http://purl.uniprot.org/citations/12847090 | http://purl.uniprot.org/core/author | "Floridi A."xsd:string |
| http://purl.uniprot.org/citations/12847090 | http://purl.uniprot.org/core/author | "Gallo R."xsd:string |
| http://purl.uniprot.org/citations/12847090 | http://purl.uniprot.org/core/author | "Gallo R."xsd:string |
| http://purl.uniprot.org/citations/12847090 | http://purl.uniprot.org/core/author | "Iezzi S."xsd:string |
| http://purl.uniprot.org/citations/12847090 | http://purl.uniprot.org/core/author | "Iezzi S."xsd:string |