| http://purl.uniprot.org/citations/12847143 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12847143 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12847143 | http://www.w3.org/2000/01/rdf-schema#comment | "NFS/N-sld mice harbor a spontaneous autosomal recessive mutation, sld (sublingual gland differentiation arrest) and histologically display attenuated mucous cell expression in sublingual glands (Hayashi et al. Am J Pathol 132: 187-191, 1988). Because altered serous demilune cell expression is unknown, we determined the phenotypic expression of this cell type in mutants. Moreover, we evaluated whether absence of glycoconjugate staining in 3-day-old mutant glands is related to disruption in apomucin gene expression and/or to posttranslational glycosylation events. Serous cell differentiation is unaffected, determined morphologically and by serous cell marker expression (PSP, parotid secretory protein; and Dcpp, demilune cell and parotid protein). Conversely, apical granules in "atypical" exocrine cells of mutant glands are PSP and mucin negative, but contain abundant SMGD (mucous granule marker). Age-related appearance of mucous cells is associated with expression of apomucin gene products, whereas SMGD expression is unaltered. "Atypical" cells thus appear specified to a mucous cell fate but do not synthesize mucin glycoproteins unless selectively induced postnatally, indicating the sld mutation disrupts apomucin transcriptional regulation and/or decreases apomucin mRNA stability."xsd:string |
| http://purl.uniprot.org/citations/12847143 | http://purl.org/dc/terms/identifier | "doi:10.1152/physiolgenomics.00151.2002"xsd:string |
| http://purl.uniprot.org/citations/12847143 | http://purl.org/dc/terms/identifier | "doi:10.1152/physiolgenomics.00151.2002"xsd:string |
| http://purl.uniprot.org/citations/12847143 | http://purl.uniprot.org/core/author | "Denny P.A."xsd:string |
| http://purl.uniprot.org/citations/12847143 | http://purl.uniprot.org/core/author | "Denny P.A."xsd:string |
| http://purl.uniprot.org/citations/12847143 | http://purl.uniprot.org/core/author | "Denny P.C."xsd:string |
| http://purl.uniprot.org/citations/12847143 | http://purl.uniprot.org/core/author | "Denny P.C."xsd:string |
| http://purl.uniprot.org/citations/12847143 | http://purl.uniprot.org/core/author | "Hand A.R."xsd:string |
| http://purl.uniprot.org/citations/12847143 | http://purl.uniprot.org/core/author | "Hand A.R."xsd:string |
| http://purl.uniprot.org/citations/12847143 | http://purl.uniprot.org/core/author | "Georgel P.T."xsd:string |
| http://purl.uniprot.org/citations/12847143 | http://purl.uniprot.org/core/author | "Georgel P.T."xsd:string |
| http://purl.uniprot.org/citations/12847143 | http://purl.uniprot.org/core/author | "Culp D.J."xsd:string |
| http://purl.uniprot.org/citations/12847143 | http://purl.uniprot.org/core/author | "Culp D.J."xsd:string |
| http://purl.uniprot.org/citations/12847143 | http://purl.uniprot.org/core/author | "Fallon M.A."xsd:string |
| http://purl.uniprot.org/citations/12847143 | http://purl.uniprot.org/core/author | "Fallon M.A."xsd:string |
| http://purl.uniprot.org/citations/12847143 | http://purl.uniprot.org/core/author | "Johar A."xsd:string |
| http://purl.uniprot.org/citations/12847143 | http://purl.uniprot.org/core/author | "Johar A."xsd:string |
| http://purl.uniprot.org/citations/12847143 | http://purl.uniprot.org/core/author | "Latchney L.R."xsd:string |
| http://purl.uniprot.org/citations/12847143 | http://purl.uniprot.org/core/author | "Latchney L.R."xsd:string |
| http://purl.uniprot.org/citations/12847143 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12847143 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12847143 | http://purl.uniprot.org/core/name | "Physiol. Genomics"xsd:string |
| http://purl.uniprot.org/citations/12847143 | http://purl.uniprot.org/core/name | "Physiol. Genomics"xsd:string |