| http://purl.uniprot.org/citations/12847224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12847224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12847224 | http://www.w3.org/2000/01/rdf-schema#comment | "The structure and T cell stimulatory effects of the recently discovered cytokine IL-23 are similar to, but distinct from, those of IL-12. Although the antitumor activities of IL-12 are well characterized, the effect of IL-23 on tumor growth is not known. In this study, murine CT26 colon adenocarcinoma and B16F1 melanoma cells were engineered using retroviral vectors to release single-chain IL-23 (scIL-23) to evaluate its antitumor activity. In BALB/c mice, scIL-23-transduced CT26 cells grew progressively until day 26 to an average size of 521 +/-333 mm(3), then the tumors started to regress in most animals, resulting in a final 70% rate of complete tumor rejection. scIL-23 transduction also significantly suppressed lung metastases of CT26 and B16F1 tumor cells. In addition, mice that rejected scIL-23-transduced tumors developed a memory response against subsequent wild-type tumor challenge. Compared with scIL-12-expressing CT26 cells, scIL-23-transduced tumors lacked the early response, but achieved comparable antitumor and antimetastatic activity. These results demonstrated that IL-23, like IL-12, provided effective protection against malignant diseases, but it probably acted by different antitumor mechanisms. As a first step in identifying these antitumor mechanisms, tumor challenge studies were performed in immunocompromised hosts and in animals selectively depleted of various lymphocyte populations. The results showed that CD8(+) T cells, but not CD4(+) T cells or NK cells, were crucial for the antitumor activity of IL-23."xsd:string |
| http://purl.uniprot.org/citations/12847224 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.171.2.600"xsd:string |
| http://purl.uniprot.org/citations/12847224 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.171.2.600"xsd:string |
| http://purl.uniprot.org/citations/12847224 | http://purl.uniprot.org/core/author | "Lee S.-C."xsd:string |
| http://purl.uniprot.org/citations/12847224 | http://purl.uniprot.org/core/author | "Lee S.-C."xsd:string |
| http://purl.uniprot.org/citations/12847224 | http://purl.uniprot.org/core/author | "Su J."xsd:string |
| http://purl.uniprot.org/citations/12847224 | http://purl.uniprot.org/core/author | "Su J."xsd:string |
| http://purl.uniprot.org/citations/12847224 | http://purl.uniprot.org/core/author | "Roffler S.R."xsd:string |
| http://purl.uniprot.org/citations/12847224 | http://purl.uniprot.org/core/author | "Roffler S.R."xsd:string |
| http://purl.uniprot.org/citations/12847224 | http://purl.uniprot.org/core/author | "Lo C.-H."xsd:string |
| http://purl.uniprot.org/citations/12847224 | http://purl.uniprot.org/core/author | "Lo C.-H."xsd:string |
| http://purl.uniprot.org/citations/12847224 | http://purl.uniprot.org/core/author | "Wu C.-W."xsd:string |
| http://purl.uniprot.org/citations/12847224 | http://purl.uniprot.org/core/author | "Wu C.-W."xsd:string |
| http://purl.uniprot.org/citations/12847224 | http://purl.uniprot.org/core/author | "Cheng C.-W."xsd:string |
| http://purl.uniprot.org/citations/12847224 | http://purl.uniprot.org/core/author | "Cheng C.-W."xsd:string |
| http://purl.uniprot.org/citations/12847224 | http://purl.uniprot.org/core/author | "Chiang B.-L."xsd:string |
| http://purl.uniprot.org/citations/12847224 | http://purl.uniprot.org/core/author | "Chiang B.-L."xsd:string |
| http://purl.uniprot.org/citations/12847224 | http://purl.uniprot.org/core/author | "Lee C.-N."xsd:string |
| http://purl.uniprot.org/citations/12847224 | http://purl.uniprot.org/core/author | "Lee C.-N."xsd:string |
| http://purl.uniprot.org/citations/12847224 | http://purl.uniprot.org/core/author | "Pan W.-Y."xsd:string |
| http://purl.uniprot.org/citations/12847224 | http://purl.uniprot.org/core/author | "Pan W.-Y."xsd:string |
| http://purl.uniprot.org/citations/12847224 | http://purl.uniprot.org/core/author | "Tao M.-H."xsd:string |
| http://purl.uniprot.org/citations/12847224 | http://purl.uniprot.org/core/author | "Tao M.-H."xsd:string |