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http://purl.uniprot.org/citations/12847896http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12847896http://www.w3.org/2000/01/rdf-schema#comment"

Aim

To assess the role of allele polymorphism of genes Fc gamma RIII and IL-10 in systemic lupus erythematosus (SLR) in a homogeneous (stratified by nationality) Kazakh population sample.

Material and methods

Polymorphism of genes Fc gamma RIIIA and IL-10 was studied in 49 patients SLE patients and 81 healthy subjects (control group). Detection of two allele variants of gene Fc gamma RIIIA (alleles F and V) caused by point mutation in position 559 was performed by polymerase chain reaction (PCR) in the amplification refractory mutation system. Genetic changeability of IL-10 gene promotion site due to point mutation in position 627 (alleles 1 and 2) was investigated by polymorphism of restricted fragment lengths using restrictase RsaI.

Results

Significant differences in the distribution rates of genes Fc gamma RIIIA and IL-10 were revealed in SLE patients versus controls. Alleles F and -627A (1), including homozygous ones, are genes predisposing to development of SLE while variants of the markers V and -627 (2) are protecting genes. If a SLE patient's genotype combines alleles F of gene Fc gamma RIII and alleles 1 of gene IL-10 (F/F + 1/1), this patient has an 8 times higher risk to develop SLE.

Conclusion

Polymorphism of genes Fc gamma RIIIA and IL-10 is associated with predisposition to development of SLE in Kazakh population. The analysis of combined genotypes of the studied genes suggests a synergic action of genes Fc gamma RIIIA and IL-10 on the risk to develop SLE."xsd:string
http://purl.uniprot.org/citations/12847896http://purl.uniprot.org/core/author"Guseva I.A."xsd:string
http://purl.uniprot.org/citations/12847896http://purl.uniprot.org/core/author"Miakotkin V.A."xsd:string
http://purl.uniprot.org/citations/12847896http://purl.uniprot.org/core/author"Omarbekova Z.h.E."xsd:string
http://purl.uniprot.org/citations/12847896http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12847896http://purl.uniprot.org/core/name"Ter Arkh"xsd:string
http://purl.uniprot.org/citations/12847896http://purl.uniprot.org/core/pages"36-41"xsd:string
http://purl.uniprot.org/citations/12847896http://purl.uniprot.org/core/title"[Polymorphism of Fc gamma RIIIA-158F/V gene and promoter region of IL-10 gene in systemic lupus erythematosus in Kazakhs]."xsd:string
http://purl.uniprot.org/citations/12847896http://purl.uniprot.org/core/volume"75"xsd:string
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